Evidence map›Paper›PMID 39046521›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Comparison of the tolerability of

Sarah D Busslinger, Ana Katrina Mapanao, Kristel Kegler, Peter Bernhardt, Fabienne Flühmann, Julia Fricke, Jan Rijn Zeevaart, Ulli Köster, Nicholas P van der Meulen, Roger Schibli and 1 more

Abstract readComparative Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Tolerability of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Evaluation of treatment efficacy of theEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Preclinical Evaluation of 5T4-Targeted [Journal of medicinal chemistry · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Materials (Basel, Switzerland) · 2025
    Article
  10. Comparison of the tolerability ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah D Busslinger *Center for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland.
Ana Katrina Mapanao *Center for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland.
Kristel KeglerAnaPath Services GmbH, Liestal, 4410, Switzerland.
Peter BernhardtDepartment of Medical Radiation Sciences, Institution of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.
Fabienne FlühmannCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland.
Julia FrickeDivision of Nuclear Medicine, University Hospital Basel, Basel, 4031, Switzerland.
Jan Rijn ZeevaartRadiochemistry, South African Nuclear Energy Corporation (Necsa), Brits, 0240, South Africa.
Ulli KösterInstitut Laue-Langevin, Grenoble, 38042, France.
Nicholas P van der MeulenCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland.
Roger SchibliCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland.
Cristina MüllerCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Villigen-PSI, 5232, Switzerland. cristina.mueller@psi.ch.ORCID http://orcid.org/0000-0001-9357-9688

Funding

ITM Medical Isotopes GmbH, Munich ITM Medical Isotopes GmbH, MunichSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 320030_188978Swedish Cancer Society Swedish Cancer SocietySwiss Cancer Research KFS-5624-08-2022the European Union's Horizon 2020 884104
6 · The paper itself

Abstract

purpose[

methodsDosimetry calculations were performed based on biodistribution data of the radiopeptides in immunocompetent mice. Treatment-related effects on blood cell counts were assessed on Days 10, 28 and 56 after application of [

resultsThe absorbed organ dose was commonly higher for the SSTR antagonist than for the SSTR agonist and for terbium-161 over lutetium-177. Application of a therapeutic activity level of 20 MBq [

conclusionHematologic changes were more pronounced in mice treated with the SSTR antagonist than in those treated with the SSTR agonist. Despite the increased absorbed dose delivered by terbium-161 over lutetium-177, [

Indexed as

LutetiumSomatostatinTerbiumAnimalsFemaleIsotope LabelingMiceOctreotideOrganometallic CompoundsRadioisotopesRadiometryRadiopharmaceuticalsTissue DistributionLutetiumLutetium-177lutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadioisotopesRadiopharmaceuticalsSomatostatinTerbiumLutetium-177Neuroendocrine neoplasmPRRTSSTR antagonistsTerbium-161

Identifiers

PMID39046521
PMCPMC11527941

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.