Evidence map›Paper›PMID 39046575›Full record

ArticleClinical oral investigations2024

Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.

Tattiana Enrich-Essvein, Santiago González-López, Alejandro B Rodríguez-Navarro, Carolina Cifuentes-Jiménez, Tatjana Maravic, Claudia Mazzitelli, Vittorio Checchi, Uros Josic, Annalisa Mazzoni, Lorenzo Breschi

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In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tattiana Enrich-EssveinDepartment of Operative Dentistry, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Maximo s/n, Granada, E-18071, Spain. tattiana@ugr.es.
Santiago González-LópezDepartment of Operative Dentistry, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Maximo s/n, Granada, E-18071, Spain.
Alejandro B Rodríguez-NavarroDepartment of Mineralogy and Petrology, Faculty of Sciences, University of Granada, Granada, Spain.
Carolina Cifuentes-JiménezDepartment of Operative Dentistry, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Maximo s/n, Granada, E-18071, Spain.
Tatjana MaravicDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Claudia MazzitelliDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Vittorio ChecchiDepartment of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Uros JosicDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Annalisa MazzoniDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Lorenzo BreschiDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effect of proanthocyanidin-functionalized hydroxyapatite nanoparticles (nHAp_PA) used as pretreatment at different concentrations on the microtensile bond strength (µTBS) and endogenous enzymatic activity (MMPs) on pH-cycled dentin after 24 h and 6 months of artificial aging. MATERIALS AND

methodsFifty human sound dentin blocks were randomly assigned to 5 groups (n = 10): (i) negative control (no treatment); (ii) positive control (pH-cycling); (iii) pH-cycling + 2% nHAp_PA for 60s; (iv) pH-cycling + 6.5% nHAp_PA for 60s; (v) pH-cycling + 15% nHAp_PA for 60s. A self-etch adhesive was used for bonding procedures before resin composite build-ups. Specimens were tested with the µTBS test after 24 h and 6 months of laboratory storage. The proteolytic activity in each group was evaluated with gelatin zymography and in situ zymography. Data were statistically analyzed (p < 0.05).

resultsAt 24 h, the µTBS of the experimental groups were significantly higher than the controls (p ≤ 0.001), and no differences were observed between different concentrations (p > 0.05). Artificial aging significantly decreased bond strength in all groups (p ≤ 0.008); however, nHAp_PA 2% still yielded higher bonding values than controls (p ≤ 0.007). The groups pretreated with nHAp_PA exhibited lower MMP-9 and MMP-2 activities compared to the positive control group and almost the same enzymatic activity as the negative control group. In situ zymography showed that after 6 months of aging, nHAp_PA 2% and nHAp_PA 6,5% decreased enzymatic activity as well as the negative control.

conclusionsDentin pretreatment with nHAp_PA increased the bonding performance of a self-etch adhesive and decreased MMP-2 and MMP-9 activities after 6 months.

Indexed as

Dental BondingDurapatiteMaterials TestingNanoparticlesProanthocyanidinsTensile StrengthComposite ResinsDental Stress AnalysisDentinDentin-Bonding AgentsHumansHydrogen-Ion ConcentrationIn Vitro TechniquesRandom AllocationSurface PropertiesComposite ResinsDentin-Bonding AgentsDurapatiteproanthocyanidinProanthocyanidinsCollagen cross-linkersDentin biomodificationMicrotensile bond strengthMMPsNanomaterialsZymography

Identifiers

PMID39046575
PMCPMC11269515

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.