Evidence map›Paper›PMID 39049203›Full record

ArticleAddiction (Abingdon, England)2025

GLP-1R agonist medications for addiction treatment.

Nora D Volkow, Rong Xu

Registry-linked trialAbstract readEditorial
In one paragraph

Article in Addiction (Abingdon, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT06745128. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06745128 phase2active not recruiting

Tirzepatide for Individuals With Comorbid Obesity and Methamphetamine Use Disorder

Ran2025Enrolled45Registered outcomes6Posted comparisons0ConditionsMethamphetamine Use Disorder, ObesityArmsTirzepatide
Open the trial in the graph
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Lost in translation: why don't dopamine D2 antagonists cure addictions?Journal of psychiatry & neuroscience : JPN · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nora D VolkowNational Institute on Drug Abuse, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-6668-0908
Rong XuCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
An Integrated Reverse Engineering Approach Toward Rapid drug Re positioning for Alzheimer's DiseaseR01AG057557 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XU, RONG · 2017 to 2021
$2.8M
Rapid reverse translational drug repositioningDP2HD084068 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI XU, RONG · 2014 to 2014
$2.4M
Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatmentsRF1AG076649 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B, XU, RONG · 2022 to 2022
$2.3M
Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatmentsR01AG076649 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI Rong Xu · 2025 to 2026
$1.6M
Characterize multifaceted interactions between COVID-19 and alcohol use disorder based on real-time analysis of electronic health records of 62 million adult patientsR01AA029831 · NIAAA · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B, XU, RONG · 2021 to 2023
$1.1M
NIAAA NIH HHS R01 AA029831NIA NIH HHS R01 AG057557NIA NIH HHS R01 AG076649NIA NIH HHS RF1 AG076649NICHD NIH HHS DP2 HD084068
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

addictioncravingGLP‐1obesitypolysubstancerelapserewardsubstance use disorder

Identifiers

PMID39049203
PMCPMC12771407

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.