Evidence map›Paper›PMID 39049677›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Role of STAT3-FOXO3 Signaling in the Modulation of Neuroplasticity by PD-L1-HGF-Decorated Mesenchymal Stem Cell-Derived Exosomes in a Murine Stroke Model.

Syuan-Ling Lin, Yi-Wen Chang, Wei Lee, Chih-Sheng Chiang, Shih-Ping Liu, Hsu-Tung Lee, Long-Bin Jeng, Woei-Cherng Shyu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Stem cell extracellular vesicles for neuropsychiatric disorders and translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  7. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
  8. Article
  9. Pro-Resolving Macrophage-Induced IL-35International journal of molecular sciences · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Exosome-Based Therapeutics in Dermatology.Biomaterials research · 2025
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Syuan-Ling LinTranslational Medicine Research Center and Department of Neurology, China Medical University Hospital, Taichung, 404, Taiwan.
Yi-Wen ChangCell Therapy Center, China Medical University Hospital, Taichung, 404, Taiwan.
Wei LeeCell Therapy Center, China Medical University Hospital, Taichung, 404, Taiwan.
Chih-Sheng ChiangCell Therapy Center, China Medical University Hospital, Taichung, 404, Taiwan.
Shih-Ping LiuTranslational Medicine Research Center and Department of Neurology, China Medical University Hospital, Taichung, 404, Taiwan.
Hsu-Tung LeeGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 114, Taiwan.
Long-Bin JengCell Therapy Center, China Medical University Hospital, Taichung, 404, Taiwan.
Woei-Cherng ShyuTranslational Medicine Research Center and Department of Neurology, China Medical University Hospital, Taichung, 404, Taiwan.ORCID 0000-0002-3335-8450

Funding

Chen-Han Foundation for EducationChina Medical University Hospital CMU104-S10China Medical University Hospital CMU104-S-15-03China Medical University Hospital DMR-104-054National Science and Technology Council MOST109-2314-B-039-025-MY2National Science and Technology Council MOST110-2314-B-039-043-MY3National Science and Technology Council NSTC113-2321-B-039-007
6 · The paper itself

Abstract

The limited therapeutic strategies available for stroke leave many patients disabled for life. This study assessed the potential of programmed death-ligand 1 (PD-L1) and hepatocyte growth factor (HGF)-engineered mesenchymal stem cell-derived exosomes (EXO-PD-L1-HGF) in enhancing neurological recovery post-stroke. EXO-PD-L1-HGF, which efficiently endocytosed into target cells, significantly diminishes the H

Indexed as

B7-H1 AntigenDisease Models, AnimalExosomesForkhead Box Protein O3Hepatocyte Growth FactorMesenchymal Stem CellsNeuronal PlasticitySignal TransductionSTAT3 Transcription FactorStrokeAnimalsMaleMiceMice, Inbred C57BLB7-H1 AntigenCd274 protein, mouseForkhead Box Protein O3FoxO3 protein, mouseHepatocyte Growth FactorHGF protein, mouseStat3 protein, mouseSTAT3 Transcription FactorexosomesHGFPD‐L1STAT3‐FOXO3 pathwaystroke

Identifiers

PMID39049677
PMCPMC11423231

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.