ArticleFrontiers in nutrition2024
Anorexia and bulimia in relation to ulcerative colitis: a Mendelian randomization study.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Plant-Based Food Preferences Rich in Polyphenols and Their Causal Effects on Inflammatory Bowel Disease.Food science & nutrition · 2026Article
- Causal effects of antibody-mediated immunity to pathogens on five ophthalmic diseases: a Mendelian randomization study.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Telomere length promotes colorectal cancer through dual parallel pathways involving growth signaling and protein metabolism.Tropical medicine and health · 2025Article
- Decoding the Spectrum of Anorexia Nervosa: Clinical Impact, Molecular Insights, and Therapeutic Perspectives.Biomolecules · 2025Review
- Genetic evidence for causal effects of inflammatory protein factors on breast cancer.Discover oncology · 2025Article
- Genetic evidence for causal relationships between vegetarian biomarkers and esophageal cancer risk.Discover oncology · 2025Article
- Autoantibodies, Oxidative Stress, and Nutritional State in Anorexia Nervosa.Antibodies (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Background: Evidence for anorexia and bulimia in relation to the risk of ulcerative colitis (UC) is limited and inconsistent. The objective of this research was to utilize bi-directional, two-sample Mendelian randomization (MR) analysis to predict the causal association between anorexia nervosa and bulimia nervosa with UC. Methods: The genome-wide association studies (GWAS) provided data for anorexia and bulimia from the UK Biobank, utilizing single-nucleotide polymorphisms (SNP) as instrumental variables. Additionally, genetic associations with UC were collected from various sources including the FinnGen Biobank, the UK Biobank and the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). The main analytical approach utilized in this study was the inverse-variance-weighted (IVW) method. To evaluate horizontal pleiotropy, the researchers conducted MR-Egger regression and MR-PRESSO global test analyses. Additionally, heterogeneity was assessed using the Cochran's Results: This study found a negative association between genetically predicted bulimia (OR = 0.943, 95% CI: 0.893-0.996; Conclusion: Genetically predicted bulimia may have a negative association with the onset of UC, while genetically predicted anorexia does not show a causal relationship with the development of UC. Conversely, genetically predicted UC may have a negative association with the development of anorexia.
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