ArticleArchives of medical science : AMS2024
The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis.
Article in Archives of medical science : AMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Association of latent class trajectories of frailty with incident symptomatic knee osteoarthritis in Chinese postmenopausal women: a nationwide cohort study from China.Scientific reports · 2026Article
- The association between frailty and headache in middle-aged and older individuals: a data analysis based on the GBD2021, the CHARLS and Mendelian randomization.Archives of medical science : AMS · 2026Article
- Exploring the association between gut microbiota and venous thromboembolism using a Mendelian randomization analysis.Archives of medical science : AMS · 2026Article
- The bidirectional relationship between knee osteoarthritis and frailty in China: A longitudinal study.The Journal of frailty & aging · 2025Article
- Visual impairment and frailty: insights from genetic correlation and Mendelian randomization.Archives of medical science : AMS · 2025Article
- Investigating the shared genetic architecture of osteoarthritis and frailty: a genome-wide cross-trait analysis.American journal of nuclear medicine and molecular imaging · 2024Article
- Circulating micronutrients and risk of stroke: a Mendelian randomisation and cross-sectional observational study.Archives of medical science : AMS · 2024Article
- Association between air pollution and bone mineral density: a Mendelian randomization study.Archives of medical science : AMS · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Osteoarthritis of the hip or knee has been reported to be linked to an increased risk of frailty. However, a definitive conclusion about whether hip or knee osteoarthritis increases susceptibility to frailty remains elusive. Material and methods: The instrumental variables (IVs) used in this analysis were sourced from publicly available genome-wide association study (GWAS) datasets. We used a two-sample Mendelian randomization analysis to evaluate the plausible causal nexus between hip or knee osteoarthritis and frailty. Results: We included a total of 25 single-nucleotide polymorphisms (SNPs) as instrumental variables through rigorous and comprehensive screening. The results of this analysis suggested that hip or knee osteoarthritis is associated with an elevated risk of frailty. These results remained robust and consistent across multiple calculation methods, including inverse variance weighted (OR = 1.082, 95% CI: 1.0532-1.1125, Conclusions: Two-sample Mendelian randomization analysis effectively identified hip or knee osteoarthritis as a contributing risk factor for frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.