ArticleThe Lancet regional health. Western Pacific2024
Association of the triglyceride-glucose index with all-cause and cause-specific mortality: a population-based cohort study of 3.5 million adults in China.
Article in The Lancet regional health. Western Pacific, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Triglyceride-Glucose Index and Mortality Risk in the General Population: A Systematic Review and Meta-analysis of Prospective Studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Pooled it
- Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.BMC neurology · 2025Pooled it
- Relationships of triglyceride-glucose-related indices with colorectal cancer incidence and mortality in an American population: a dose-response meta-analysis and cohort study.Lipids in health and disease · 2025Pooled it
- The association of triglyceride-glucose index with cancer incidence and mortality: a systematic review and meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Glycemic and lipid responses to selenium-enriched vs. zeaxanthin-enriched eggs in patients with type 2 diabetes: a 12-week randomized controlled trial.Frontiers in nutrition · 2026Trial
- Nine anthropometric insulin resistance indices predict mortality and life expectancy across glucose states.iScience · 2026Article
- Associations between prediabetes, type 2 diabetes and incident atrial fibrillation in patients with hypertension: Results from the Swedish Primary Care Cardiovascular Database.American journal of preventive cardiology · 2026Article
- Nonlinear association of triglyceride-glucose body mass index with all-cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Short-term trajectories of TyG-WHtR and hs-CRP and their joint impact on stroke risk in early CKM syndrome: evidence from Chinese national cohort.Scientific reports · 2026Article
- Association of the C-reactive protein-triglyceride glucose index with all-cause and cardiovascular mortality among U.S. adults with metabolic dysfunction-associated steatotic liver disease: a national cohort study.Cardiovascular diabetology · 2026Article
- Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4.Cardiovascular diabetology · 2026Article
- Association and predictive performance of the ZJU index for incident cardiometabolic multimorbidity in middle-aged and older adults: a 10-year prospective cohort study.Journal of health, population, and nutrition · 2026Article
- Post-treatment triglyceride-glucose index as survival protective factors in patients with esophageal squamous cell carcinoma.World journal of clinical oncology · 2026Article
- Association between triglyceride-glucose index and long-term frailty progression and transition in Chinese adults.Scientific reports · 2026Article
- Baseline triglyceride-cholesterol-body weight index and risk of incident cardiovascular disease: evidence from the CHARLS and ELSA cohorts.Frontiers in nutrition · 2026Article
- Triglyceride-glucose index, CKM stage, and absolute benefit of intensive blood pressure control: aFrontiers in nutrition · 2026Article
- Triglyceride-glucose index and subclinical left ventricular dysfunction across cardiovascular-kidney-metabolic syndrome stages: a 7-year retrospective cohort study.Frontiers in endocrinology · 2026Article
- The metabolic-inflammatory axis in chronic heart failure: integrating the NLR and TyG index for recent-onset atrial fibrillation prediction via machine learning and mediation analysis.Frontiers in endocrinology · 2026Article
- Triglyceride-glucose index, HOmeostatic Model Assessment index, and new-onset hypertension in middle-aged men.Journal of hypertension · 2026Article
- Association between atherosclerosis-related indicators and fatty liver: a population-based observational study.European journal of medical research · 2025Observational
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The triglyceride-glucose (TyG) index has been recognized as a crucial risk factor for cardiovascular diseases. However, the association between the TyG index and mortality in the general population remains elusive. Methods: Participants were enrolled from the China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART), a nationwide prospective cohort study. The outcomes of interest were all-cause, cardiovascular, and cancer mortality. Restricted cubic splines and Cox regression models were used to assess the associations between the TyG index and outcomes. Findings: In total, 3,524,459 participants with a median follow-up of 4.6 (IQR, 3.1-5.8) years were included. The associations of the TyG index with all-cause and cardiovascular mortality were reverse L-shaped, with cut-off values of 9.75 for all-cause mortality and 9.85 for cardiovascular mortality. For each 1-unit increase in the TyG index, when below the cut-off values, the TyG index was not significantly associated with all-cause mortality (HR = 1.02, 95% CI: 1.00-1.03) and was only modestly associated with cardiovascular mortality (HR = 1.09, 95% CI: 1.06-1.11). Conversely, when the cut-off values were exceeded, the HRs (95% CI) were 2.10 (1.94-2.29) for all-cause mortality and 1.99 (1.72-2.30) for cardiovascular mortality. However, the association between the TyG index and cancer mortality was linearly negative (HR = 0.97, 95% CI: 0.94-0.99). Interpretation: The associations of the TyG index with all-cause and cardiovascular mortality displayed reverse L-shaped patterns, while an elevated TyG index showed a slight negative association with cancer mortality. We suggest that <9.75 could be the optimal TyG index cut-off value among the Chinese general population. Individuals at high risk of mortality might benefit from proper management of a high TyG index. Funding: The National High Level Hospital Clinical Research Funding (2023-GSP-ZD-2, 2023-GSP-RC-01), the Ministry of Finance of China and National Health Commission of China.
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