ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024
[Causal relationship between gut microbiota and pigmented villonodular synovitis: a Mendelian randomization analysis].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectiveTo investigate the causal relationship between gut microbiota and pigmented villonodular synovitis using Mendelian randomization analysis.
methodsWe conducted a two-sample Mendelian randomization analysis to investigate the causal relationship between 211 gut microbiome taxa and pigmented villonodular synovitis based on GWAS summary data, with inverse variance weighted (IVW) analysis as the primary result and the other methods as supplementary analyses. The reliability of the results was tested using Cochran's Q test, MR-Egger regression, MR-PRESSO method and conditional Mendelian randomization analysis (cML-MA).
resultsThe increased abundance of Barnesiella (OR=3.12, 95%
conclusionIncreased abundance of specific intestinal microorganisms is associated with increased or decreased risks of developing hyperpigmented villonodular synovitis, and gut microbiota plays an important role in the pathogenesis of this disease.
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