Evidence map›Paper›PMID 39051337›Full record

ArticleBiotech (Basel (Switzerland))2024

A Machine Learning-Based Web Tool for the Severity Prediction of COVID-19.

Avgi Christodoulou, Martha-Spyridoula Katsarou, Christina Emmanouil, Marios Gavrielatos, Dimitrios Georgiou, Annia Tsolakou, Maria Papasavva, Vasiliki Economou, Vasiliki Nanou, Ioannis Nikolopoulos and 7 more

Abstract read
In one paragraph

Article in Biotech (Basel (Switzerland)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Avgi ChristodoulouResearch Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Martha-Spyridoula KatsarouResearch Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Christina EmmanouilCentre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0009-0006-2421-2181
Marios GavrielatosCentre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Dimitrios GeorgiouCentre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0009-0009-8481-5605
Annia TsolakouResearch Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Maria PapasavvaDepartment of Pharmacy, School of Health Sciences, Frederick University, 1036 Nicosia, Cyprus.
Vasiliki EconomouResearch Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Vasiliki NanouSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
Ioannis NikolopoulosSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
Maria DaganouSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.ORCID 0009-0001-1726-5086
Aikaterini ArgyrakiSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.ORCID 0000-0002-9095-7724
Evaggelos StefanidisSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
Gerasimos MetaxasSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.
Emmanouil PanagiotouSotiria Thoracic Diseases Hospital of Athens, 11527 Athens, Greece.ORCID 0000-0002-4243-0434
Ioannis MichalopoulosCentre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-8991-8712
Nikolaos DrakoulisResearch Group of Clinical Pharmacology and Pharmacogenomics Faculty of Pharmacy, School oh Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.ORCID 0000-0002-7545-8089

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predictive tools provide a unique opportunity to explain the observed differences in outcome between patients of the COVID-19 pandemic. The aim of this study was to associate individual demographic and clinical characteristics with disease severity in COVID-19 patients and to highlight the importance of machine learning (ML) in disease prognosis. The study enrolled 344 unvaccinated patients with confirmed SARS-CoV-2 infection. Data collected by integrating questionnaires and medical records were imported into various classification machine learning algorithms, and the algorithm and the hyperparameters with the greatest predictive ability were selected for use in a disease outcome prediction web tool. Of 111 independent features, age, sex, hypertension, obesity, and cancer comorbidity were found to be associated with severe COVID-19. Our prognostic tool can contribute to a successful therapeutic approach via personalized treatment. Although at the present time vaccination is not considered mandatory, this algorithm could encourage vulnerable groups to be vaccinated.

Indexed as

agecancerhypertensionmachine learningobesitySARS-CoV-2severe COVID-19sex

Identifiers

PMID39051337
PMCPMC11270362

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.