Evidence map›Paper›PMID 39051413›Full record

ArticleHematology reports2024

A Rare Onset of T-Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations.

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Abstract readCase Reports
In one paragraph

Article in Hematology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandra MongiaGeneral Laboratory, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Francesca RomanoGeneral Laboratory, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Sara Ciullini MannuritaGeneral Laboratory, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Benedetta PeruzziFlow Cytometric and Immunotherapeutic Diagnostic Center, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Sara BenciniFlow Cytometric and Immunotherapeutic Diagnostic Center, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Daniela ParriniGenetic Diagnosis Service, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Laura FasanoHematology Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.
Alessandra FanelliGeneral Laboratory, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by bone marrow expansion and the proliferation of one or more myeloid cell lineages, predominantly driven by the expression of the constitutively active fusion product tyrosine kinase BCR:ABL1. Rarely, CML patients directly develop a blast crisis (BC), mostly of myeloid origin. CML at blast crisis with a T-cell phenotype at diagnosis, without any prior history of CML, is extremely rare. Herein, we describe one rare CML case, in a young man showing an unusual and early T-lymphoid blastic crisis at diagnosis, as the first onset of a previously unknown CML. The multidisciplinary collaboration between laboratorians and clinicians for the diagnosis and management of this atypical case was crucial in outlining both a targeted pharmacological treatment and a successful hematopoietic stem cell transplantation.

Indexed as

chronic myeloid leukemiaT-lymphoid blastic crisis

Identifiers

PMID39051413
PMCPMC11431131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.