Evidence map›Paper›PMID 39052479›Full record

ArticleCell reports2024

Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function.

Hannah Guak, Matthew Weiland, Alexandra Vander Ark, Lukai Zhai, Kin Lau, Mario Corrado, Paula Davidson, Ebenezer Asiedu, Batsirai Mabvakure, Shelby Compton and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Emerging role ofFrontiers in molecular neuroscience · 2026
    Article
  5. Article
  6. Recent Advances in Host Immune Mechanisms AgainstJournal of inflammation research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hannah GuakDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew WeilandDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Alexandra Vander ArkDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Lukai ZhaiDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Kin LauBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI 49503, USA.
Mario CorradoDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Internal Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada.
Paula DavidsonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Ebenezer AsieduDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Batsirai MabvakureDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA; Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Shelby ComptonDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Lisa DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Catherine A ScullionDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA; Department of Experimental Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Russell G JonesDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Sara M NowinskiDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA.
Connie M KrawczykDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address: connie.krawczyk@vai.org.

Funding

NIAID NIH HHS R21 AI153997
6 · The paper itself

Abstract

Functional and phenotypic heterogeneity of dendritic cells (DCs) play crucial roles in facilitating the development of diverse immune responses essential for host protection. Here, we report that KDM5C, a histone lysine demethylase, regulates conventional or classical DC (cDC) and plasmacytoid DC (pDC) population heterogeneity and function. Mice deficient in KDM5C in DCs have increased proportions of cDC2Bs and cDC1s, which is partly dependent on type I interferon (IFN) and pDCs. Loss of KDM5C results in an increase in Ly6C

Indexed as

CD8-Positive T-LymphocytesDendritic CellsHistone DemethylasesAnimalsAntigen PresentationInterferon Type IMiceMice, Inbred C57BLTranscription, GeneticHistone DemethylasesInterferon Type IKdm5c protein, mouseantigen presentationCP: ImmunologyCP: Molecular biologyDC developmentdendritic cellsepigeneticshistone demethylaseinterferonIRFIRF8KDM5Cmetabolism

Identifiers

PMID39052479
PMCPMC11416765

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.