Evidence map›Paper›PMID 39052712›Full record

ArticleThe Journal of infectious diseases2024

Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.

Cornelia A M van de Weg, Mateus V Thomazella, Mariana P Marmorato, Carolina A Correia, Juliana Z C Dias, Alvino Maestri, Luiz G F A B E Zanella, Natalia B Cerqueira, Alvina C Félix, Carlos H V Moreira and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Early Dysregulation of Angiopoietin-1 and -2 as a Predictor of Mortality in Critically Ill Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cornelia A M van de WegMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Mateus V ThomazellaMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.ORCID 0000-0002-1527-6910
Mariana P MarmoratoMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Carolina A CorreiaMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Juliana Z C DiasMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Alvino MaestriMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Luiz G F A B E ZanellaMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Natalia B CerqueiraSchool of Medicine, Hospital das Clínicas, Sã‌o Paulo, Brazil.
Alvina C FélixInstitute of Tropical Medicine, University of São Paulo, São Paulo, Brazil‌.
Carlos H V MoreiraInfectious Diseases Institute "Emílio Ribas", São Paulo, Brazil‌.
Renata BuccheriInfectious Diseases Institute "Emílio Ribas", São Paulo, Brazil‌.
Priscilla R CostaMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.
Esper G KallásMedical Investigation Laboratory 60, School of Medicine, University of São Paulo, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorSão Paulo Research Foundation 2016/01735-2
6 · The paper itself

Abstract

In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.

Indexed as

Angiopoietin-2BiomarkersYellow FeverYellow fever virusAdultAgedBrazilCase-Control StudiesFemaleHumansMaleMiddle AgedYoung AdultAngiopoietin-2ANGPT2 protein, humanBiomarkersangiopoietin 2endothelial damageyellow fever

Identifiers

PMID39052712
PMCPMC11272082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.