Evidence map›Paper›PMID 39052845›Full record

ReviewAmerican journal of physiology. Renal physiology2024

Actin cytoskeleton and associated myosin motors within the renal epithelium.

Brook W Busselman, Ishara Ratnayake, Mark R Terasaki, Vedant P Thakkar, Arooba Ilyas, Karla L Otterpohl, Jenna L Zimmerman, Indra Chandrasekar

Abstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brook W BusselmanEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.ORCID 0000-0003-3349-6316
Ishara RatnayakeVan Andel Institute, Grand Rapids, Michigan, United States.
Mark R TerasakiDepartment of Cell Biology, University of Connecticut, Farmington, Connecticut, United States.
Vedant P ThakkarEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.
Arooba IlyasEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.
Karla L OtterpohlEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.
Jenna L ZimmermanEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.
Indra ChandrasekarEnabling Technologies Group, Sanford Research, Sioux Falls, South Dakota, United States.ORCID 0000-0003-3822-0570

Funding

Uncovering cargo and cell type specific molecular mechanisms of renal tubular epithelial transportR01DK131020 · NIDDK · SANFORD RESEARCH/USD · PI Indra Chandrasekar · 2022 to 2026
$1.8M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK131020NIDDK NIH HHS R01 DK131020
6 · The paper itself

Abstract

This review highlights the complexity of renal epithelial cell membrane architectures and organelles through careful review of ultrastructural and physiological studies published over the past several decades. We also showcase the vital roles played by the actin cytoskeleton and actin-associated myosin motor proteins in regulating cell type-specific physiological functions within the cells of the renal epithelium. The purpose of this review is to provide a fresh conceptual framework to explain the structure-function relationships that exist between the actin cytoskeleton, organelle structure, and cargo transport within the mammalian kidney. With recent advances in technologies to visualize the actin cytoskeleton and associated proteins within intact kidneys, it has become increasingly imperative to reimagine the functional roles of these proteins in situ to provide a rationale for their unique, cell type-specific functions that are necessary to establish and maintain complex physiological processes.

Indexed as

Actin CytoskeletonKidneyMyosinsActinsAnimalsEpithelial CellsEpitheliumHumansActinsMyosinsactinmyosinorganellesrenal epitheliumultrastructure

Identifiers

PMID39052845
PMCPMC11483076

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.