Evidence map›Paper›PMID 39053573›Full record

ArticleJournal of molecular and cellular cardiology2024

Ryanodine receptor stabilization therapy suppresses Ca

Aaron D Kaplan, Liron Boyman, Christopher W Ward, W Jonathan Lederer, Maura Greiser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Aaron D KaplanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; Division of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Liron BoymanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA; Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Christopher W WardCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA; Claude D. Pepper Older Americans Independence Center, University of Maryland School of Medicine, Baltimore, MD, USA.
W Jonathan LedererCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA; Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Maura GreiserCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA; Claude D. Pepper Older Americans Independence Center, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: mgreiser@som.umaryland.edu.

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir, Karen J. Bandeen-Roche · 2003 to 2026
$33.2M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Leslie I. Katzel, ALICE S. RYAN · 2006 to 2026
$28.9M
Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Microtubule Regulated Mechanotransduction in Skeletal MuscleR01AR071618 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WARD, CHRISTOPHER WILLIAM · 2017 to 2021
$2.6M
Osteocyte CaMKII as a Critical Regulator of Bone Physiology and AnabolismR01AR071614 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Joseph P. Stains · 2018 to 2026
$2.6M
Extracellular miRNAs, innate immunity, and critical illnessR35GM140822 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WEI CHAO · 2021 to 2026
$2.5M
Stretch-Dependent Calcium Signaling in HeartR01HL106059 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL106059NHLBI NIH HHS R01 HL142290NHLBI NIH HHS U01 HL116321NIAID NIH HHS U19 AI090959NIAMS NIH HHS R01 AR071618NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG028747NIGMS NIH HHS R35 GM140822
6 · The paper itself

Abstract

Heart Failure with preserved ejection fraction (HFpEF) has a high rate of sudden cardiac death (SCD) and empirical treatment is ineffective. We developed a novel preclinical model of metabolic HFpEF that presents with stress-induced ventricular tachycardia (VT). Mechanistically, we discovered arrhythmogenic changes in intracellular Ca

Indexed as

Arrhythmias, CardiacCalciumDantroleneDisease Models, AnimalHeart FailureRyanodine Receptor Calcium Release ChannelAnimalsCalcium SignalingHumansMaleMiceMyocytes, CardiacStroke VolumeTachycardia, VentricularCalciumDantroleneRyanodine Receptor Calcium Release ChannelArrhythmiaCalcium handlingHeart failureMetabolic stress

Identifiers

PMID39053573
PMCPMC11826478

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.