Evidence map›Paper›PMID 39055936›Full record

ArticleiScience2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells.

Zhimin Zhou, Maolian Gong, Amit Pande, Anca Margineanu, Ulrike Lisewski, Bettina Purfürst, Han Zhu, Lei Liang, Shiqi Jia, Sebastian Froehler and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Zhimin ZhouMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Maolian GongMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Amit PandeMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Anca MargineanuMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Ulrike LisewskiExperimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, 13125 Berlin, Germany.
Bettina PurfürstMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Han ZhuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Lei LiangDepartment of Pediatrics, Anhui Provincial Children's Hospital, Hefei 23000, China.
Shiqi JiaThe First Affiliated Hospital of Jinan University, Guangzhou 510000, China.
Sebastian FroehlerMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Chun ZengDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Peter KühnenCharité, Universitätsmedizin Berlin, Virchow-Klinikum, 13125 Berlin, Germany.
Semik KhodaverdiDepartment of Pediatrics, Klinikum Hanau, 63450 Hanau, Germany.
Winfried KrillDepartment of Pediatrics, Klinikum Hanau, 63450 Hanau, Germany.
Torsten RöpkeExperimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, 13125 Berlin, Germany.
Wei ChenDepartment of Biology, Southern University of Science and Technology, Shenzhen 518000, China.
Klemens RaileCharité, Universitätsmedizin Berlin, Virchow-Klinikum, 13125 Berlin, Germany.
Maike SanderMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.
Zsuzsanna IzsvákMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.

Funding

Nkx6 gene function in pancreas developmentR01DK068471 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WORTHAM, MATTHEW · 2004 to 2024
$6.6M
A 3D vascularized islet biomimetic to model type 1 diabetesUG3DK122639 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUGHES, CHRISTOPHER C. W., SANDER, MAIKE · 2019 to 2020
$2.1M
NIDDK NIH HHS R01 DK068471NIDDK NIH HHS UG3 DK122639
6 · The paper itself

Abstract

KCNQ1/Kv7, a low-voltage-gated K

Indexed as

Biological sciencesEndocrinologyHealth sciencesInternal medicineMedical specialtyMedicineNatural sciencesPhysiology

Identifiers

PMID39055936
PMCPMC11269803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.