Evidence map›Paper›PMID 39056117›Full record

ArticleDisease models & mechanisms2024

Characterization of a monkey model with experimental retinal damage induced by N-methyl-D-aspartate.

Guo Liu, Longxiang Huang, Junkai Tan, Yun Wang, Chunlin Lan, Yaxi Chen, Yukai Mao, Xizhen Wang, Ning Fan, Yihua Zhu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guo LiuSichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.ORCID 0000-0001-5596-4227
Longxiang HuangThe First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.ORCID 0000-0002-8564-4221
Junkai TanXiamen Eye Center, Xiamen University, Xiamen, 361004, China.ORCID 0000-0003-0279-1355
Yun WangShenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, 518040, China.ORCID 0000-0002-6073-6242
Chunlin LanThe First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.ORCID 0000-0002-5022-1704
Yaxi ChenShenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, 518040, China.ORCID 0009-0006-8578-5020
Yukai MaoThe First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.ORCID 0009-0006-2734-2694
Xizhen WangShenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, 518040, China.ORCID 0000-0001-5718-0530
Ning FanShenzhen Key Laboratory of Ophthalmology, Shenzhen Eye Hospital, Jinan University, Shenzhen, 518040, China.ORCID 0000-0003-2303-4441
Yihua ZhuThe First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.ORCID 0000-0003-2491-669X
Xianjun ZhuSichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.ORCID 0000-0002-2531-7552
Xuyang LiuXiamen Eye Center, Xiamen University, Xiamen, 361004, China.ORCID 0000-0002-0103-0098

Funding

Chinese Academy of Medical Sciences 2019-12M-5-032National Natural Science Foundation of China 82070963Science and Technology Department of Sichuan Province 23ZYKJCX0013Sichuan Provincial People's Hospital 2022BH02
6 · The paper itself

Abstract

N-methyl-D-aspartate (NMDA)-induced retinal damage has been well studied in rodents, but the detailed mechanisms have not yet been characterized in nonhuman primates. Here, we characterized the retinal degenerative effects of NMDA on rhesus monkeys in vivo. NMDA saline or saline-only control was injected intravitreally to the randomly assigned eyes and contralateral eyes of four rhesus monkeys, respectively. The structural and functional changes of retina were characterized by optical coherence tomography and electroretinography on days 0, 4, 30 and 60 post injection. Both optic discs and macular areas of the NMDA-injected eyes initially presented with a transient retinal thickening, followed by continued retinal thinning. The initial, transient retinal thickening has also been observed in glaucoma patients, but this has not been reported in rodent NMDA models. This initial response was followed by loss of retina ganglion cells (RGCs), which is similar to glaucomatous optic neuropathy and other RGC-related retinal degenerations. The amplitudes of both the photopic negative response and pattern electroretinogram decreased significantly and remained low until the end of the study. Thus, the NMDA monkey model may serve as a more clinically relevant animal model of retinal damage.

Indexed as

Disease Models, AnimalElectroretinographyMacaca mulattaN-MethylaspartateRetinaTomography, Optical CoherenceAnimalsMaleRetinal Ganglion CellsN-MethylaspartateElectroretinographyMonkey modelNMDAOptical coherence tomographyRetinal damage

Identifiers

PMID39056117
PMCPMC11554257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.