Evidence map›Paper›PMID 39056776›Full record

ArticleCells2024

Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder.

Daniel J Schill, Durga Attili, Cynthia J DeLong, Melvin G McInnis, Craig N Johnson, Geoffrey G Murphy, K Sue O'Shea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Novel advanced patient-derivedFrontiers in neurology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel J SchillDepartment of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5790-7744
Durga AttiliDepartment of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.
Cynthia J DeLongDepartment of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.
Melvin G McInnisDepartment of Psychiatry, The University of Michigan, Ann Arbor, MI 48109, USA.
Craig N JohnsonDepartment of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3955-7394
Geoffrey G MurphyDepartment of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA.
K Sue O'SheaDepartment of Cell and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3647-9063

Funding

NIMH National Cooperative Reprogrammed Cell Research Groups NCRCRG U19 NIMH106434
6 · The paper itself

Abstract

Bipolar disorder (BP) is a recurring psychiatric condition characterized by alternating episodes of low energy (depressions) followed by manias (high energy). Cortical network activity produced by GABAergic interneurons may be critical in maintaining the balance in excitatory/inhibitory activity in the brain during development. Initially, GABAergic signaling is excitatory; with maturation, these cells undergo a functional switch that converts GABA

Indexed as

Bipolar DisorderCell DifferentiationGABAergic NeuronsInduced Pluripotent Stem CellsHumansInterneuronsSolute Carrier Family 12, Member 2SLC12A2 protein, humanSolute Carrier Family 12, Member 2GABA switchgamma-aminobutyric acidKCC2neuronNKCC1patientskin biopsySLC12A2SLC12A5somatostatinstem cell

Identifiers

PMID39056776
PMCPMC11275104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.