Evidence map›Paper›PMID 39056800›Full record

ArticleCells2024

Enhanced Migration of Fuchs Corneal Endothelial Cells by Rho Kinase Inhibition: A Novel Ex Vivo Descemet's Stripping Only Model.

Mohit Parekh, Annie Miall, Ashley Chou, Lara Buhl, Neha Deshpande, Marianne O Price, Francis W Price, Ula V Jurkunas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohit ParekhSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.ORCID 0000-0002-5186-068X
Annie MiallSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.ORCID 0000-0001-7493-914X
Ashley ChouFaculty of Arts and Sciences, Harvard College, Boston, MA 02138, USA.
Lara BuhlWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Neha DeshpandeSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.
Marianne O PriceCornea Research Foundation of America, Indianapolis, IN 46260, USA.ORCID 0000-0002-6652-534X
Francis W PriceCornea Research Foundation of America, Indianapolis, IN 46260, USA.
Ula V JurkunasSchepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA.

Funding

Kowa company ltd. N/A
6 · The paper itself

Abstract

Descemet's Stripping Only (DSO) is a surgical technique that utilizes the peripheral corneal endothelial cell (CEnC) migration for wound closure. Ripasudil, a Rho-associated protein kinase (ROCK) inhibitor, has shown potential in DSO treatment; however, its mechanism in promoting CEnC migration remains unclear. We observed that ripasudil-treated immortalized normal and Fuchs endothelial corneal dystrophy (FECD) cells exhibited significantly enhanced migration and wound healing, particularly effective in FECD cells. Ripasudil upregulated mRNA expression of Snail Family Transcriptional Repressor (

Indexed as

Cell MovementFuchs' Endothelial Dystrophyrho-Associated KinasesCell ProliferationDescemet MembraneDescemet Stripping Endothelial KeratoplastyEndothelial CellsEndothelium, CornealEpithelial-Mesenchymal TransitionHumansIsoquinolinesModels, BiologicalProtein Kinase InhibitorsSulfonamidesWound HealingIsoquinolinesK-115Protein Kinase Inhibitorsrho-Associated KinasesSulfonamidescellscorneacorneal endotheliumDescemet’s Stripping OnlyFuchs endothelial corneal dystrophymigrationROCK inhibitor

Identifiers

PMID39056800
PMCPMC11274477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.