Evidence map›Paper›PMID 39056803›Full record

ArticleCells2024

A Transcriptomics Analysis of the Regulation of Lens Fiber Cell Differentiation in the Absence of FGFRs and PTEN.

Anil Upreti, Stephanie L Padula, Jacob M Weaver, Brad D Wagner, Allison M Kneller, Anthony L Petulla, Salil A Lachke, Michael L Robinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anil UpretiCell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.ORCID 0000-0001-8502-6506
Stephanie L PadulaCell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Jacob M WeaverCell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.
Brad D WagnerDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.
Allison M KnellerDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.
Anthony L PetullaDepartment of Biology and Center for Visual Sciences, Miami University, Oxford, OH 45056, USA.
Salil A LachkeDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.ORCID 0000-0001-8845-010X
Michael L RobinsonCell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA.ORCID 0000-0003-4779-3426

Funding

POST TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN THE LENS (LENS GENE EXPRESSIONR01EY021505 · NEI · WASHINGTON UNIVERSITY · PI LACHKE, SALIL · 2011 to 2024
$5.3M
THE ROLE OF FGF RECPETORS IN LENS DEVELOPMENTR01EY012995 · NEI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI ROBINSON, MICHAEL L · 2000 to 2018
$4.9M
Investigating the role of NKX6-1 in secondary lens fiber cell differentiationR21EY031092 · NEI · MIAMI UNIVERSITY OXFORD · PI ROBINSON, MICHAEL L · 2020 to 2021
$392k
NEI NIH HHS R01 EY012995NEI NIH HHS R01 EY012995, R21 EY031092NEI NIH HHS R01 EY021505NEI NIH HHS R21 EY031092
6 · The paper itself

Abstract

Adding 50% vitreous humor to the media surrounding lens explants induces fiber cell differentiation and a significant immune/inflammatory response. While

Indexed as

Cell DifferentiationLens, CrystallinePTEN PhosphohydrolaseAnimalsGene Expression ProfilingMiceSignal TransductionTranscriptomePTEN PhosphohydrolasePten protein, mouseEMTFGFRsinflammationlenslens explantsPDGFRsPTENRNA-seq

Identifiers

PMID39056803
PMCPMC11274593

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.