ReviewJournal of functional biomaterials2024
The Incorporation of Zinc into Hydroxyapatite and Its Influence on the Cellular Response to Biomaterials: A Systematic Review.
Review in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Innovative Hydroxyapatite-Hydrogel Composites for Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- A promising therapeutic biomaterial: CHX@ZnO-HA/PSSS nanocomposites enable pH-Dependent infection eradication and bone regeneration in osteomyelitis.Journal of Taibah University Medical Sciences · 2026Article
- Sulfur Species in Zinc-Rich Condylar Zones of a Rat Temporomandibular Joint.Journal of dental research · 2026Article
- (Ca/Zn)COACS omega · 2026Article
- Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair.Frontiers in bioengineering and biotechnology · 2026Article
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
- Experimental investigation on enhancing the mechanical properties of biodegradable Zn-3Mg alloys reinforced with snail-shell particulates via powder metallurgy.Journal of materials science. Materials in medicine · 2025Article
- New NaBMC chemistry · 2025Article
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Targeting metastasis in paediatric bone sarcomas.Molecular cancer · 2025Review
- Assessment of Quality in Antimicrobial Calcium Phosphate Research (AQUACAP): A Systematic Review.Materials (Basel, Switzerland) · 2025Review
- New Nanobioceramics Based on Hydroxyapatite for Biomedical Applications: Stability and Properties.Nanomaterials (Basel, Switzerland) · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.Frontiers in bioengineering and biotechnology · 2025Review
- Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects.International journal of nanomedicine · 2025Review
- Revisiting Physicochemical and Biological Properties of ZnNanotechnology, science and applications · 2025Article
- Selenium-containing nanoparticles and bone related disorders: from synthesis, bone metabolism to disease therapy.Frontiers in endocrinology · 2025Review
- Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering.International journal of molecular sciences · 2024Article
- In Vitro Evaluation of Cellular Interactions with Nanostructured Spheres of Alginate and Zinc-Substituted Carbonated Hydroxyapatite.Materials (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is known for its role in enhancing bone metabolism, cell proliferation, and tissue regeneration. Several studies proposed the incorporation of zinc into hydroxyapatite (HA) to produce biomaterials (ZnHA) that stimulate and accelerate bone healing. This systematic review aimed to understand the physicochemical characteristics of zinc-doped HA-based biomaterials and the evidence of their biological effects on osteoblastic cells. A comprehensive literature search was conducted from 2022 to 2024, covering all years of publications, in three databases (Web of Science, PUBMED, Scopus), retrieving 609 entries, with 36 articles included in the analysis according to the selection criteria. The selected studies provided data on the material's physicochemical properties, the methods of zinc incorporation, and the biological effects of ZnHA on bone cells. The production of ZnHA typically involves the wet chemical synthesis of HA and ZnHA precursors, followed by deposition on substrates using processes such as liquid precursor plasma spraying (LPPS). Characterization techniques confirmed the successful incorporation of zinc into the HA lattice. The findings indicated that zinc incorporation into HA at low concentrations is non-cytotoxic and beneficial for bone cells. ZnHA was found to stimulate cell proliferation, adhesion, and the production of osteogenic factors, thereby promoting in vitro mineralization. However, the optimal zinc concentration for the desired effects varied across studies, making it challenging to establish a standardized concentration. ZnHA materials are biocompatible and enhance osteoblast proliferation and differentiation. However, the mechanisms of zinc release and the ideal concentrations for optimal tissue regeneration require further investigation. Standardizing these parameters is essential for the effective clinical application of ZnHA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.