Evidence mapPaperPMID 39059357Full record

ReviewCell2024

Diabetes mellitus-Progress and opportunities in the evolving epidemic.

E Dale Abel, Anna L Gloyn, Carmella Evans-Molina, Joshua J Joseph, Shivani Misra, Utpal B Pajvani, Judith Simcox, Katalin Susztak, Daniel J Drucker

Abstract readReview
In one paragraph

Review in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 3 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

E Dale AbelDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address: domchair_daleabel@mednet.ucla.edu.
Anna L GloynDepartment of Pediatrics, Division of Endocrinology & Diabetes, Department of Genetics, Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA.
Carmella Evans-MolinaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Joshua J JosephDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Columbus, OH, USA.
Shivani MisraDepartment of Metabolism, Digestion and Reproduction, Imperial College London, and Imperial College NHS Trust, London, UK.
Utpal B PajvaniDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Judith SimcoxHoward Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Katalin SusztakRenal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Daniel J DruckerLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.

Funding

Interferon Signaling in the T1D Islet MicroenvironmentU01DK127786 · UNIVERSITY OF CHICAGO · 2025 to 2025
$3.5M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2025 to 2025
$3.0M
Stanford Islet Research CoreP30DK116074 · STANFORD UNIVERSITY · 2025 to 2025
$2.0M
Translation CoreP30DK097512 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$1.7M
Jagged-Notch signaling in NASH/fibrosisR01DK119767 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 to 2025
$1.0M
Molecular Precision Nephrology CoreP50DK114786 · CHILDREN'S HOSP OF PHILADELPHIA · 2025 to 2025
$873k
Linking education, produce provision, and community referrals to improve diabetes care (LINK)R01DK132403 · OHIO STATE UNIVERSITY · 2025 to 2025
$659k
Implications of Changes in Islet Exosomal Cargo in Type 1 DiabetesR01DK133881 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$653k
Adaptive and maladaptive repair after kidney injuryR01DK076077 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$566k
The role of cytosolic nucleotide sensors in inflammatory fibrosisR01DK132630 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$505k
Indiana University clinical Center for acute pancreatitis and diabetes clinical research networkU01DK127382 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$505k
Epigenetics of Chronic Kidney DiseaseR01DK087635 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KATALIN SUSZTAK · 2023 to 2023
$485k
AHRQ HHS R01 HS028822BLRD VA I01 BX001733NHLBI NIH HHS R61 HL141783NIDDK NIH HHS P30 DK097512NIDDK NIH HHS P30 DK116074NIDDK NIH HHS P50 DK114786NIDDK NIH HHS R01 DK076077NIDDK NIH HHS R01 DK087635NIDDK NIH HHS R01 DK103818NIDDK NIH HHS R01 DK105821NIDDK NIH HHS R01 DK119767NIDDK NIH HHS R01 DK125079NIDDK NIH HHS R01 DK127236NIDDK NIH HHS R01 DK127308NIDDK NIH HHS R01 DK132403NIDDK NIH HHS R01 DK132630NIDDK NIH HHS R01 DK133479NIDDK NIH HHS R01 DK133881NIDDK NIH HHS U01 DK123743NIDDK NIH HHS U01 DK127382NIDDK NIH HHS U01 DK127786NIDDK NIH HHS U24 DK098085NIDDK NIH HHS UC4 DK104166NIDDK NIH HHS UM1 DK126185Wellcome Trust
6 · The paper itself

Abstract

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skeletal muscle, and liver. Type 1 diabetes (T1D) results from immune-mediated beta cell destruction. The more prevalent type 2 diabetes (T2D) is a heterogeneous disorder characterized by varying degrees of beta cell dysfunction in concert with insulin resistance. The strong association between obesity and T2D involves pathways regulated by the central nervous system governing food intake and energy expenditure, integrating inputs from peripheral organs and the environment. The risk of developing diabetes or its complications represents interactions between genetic susceptibility and environmental factors, including the availability of nutritious food and other social determinants of health. This perspective reviews recent advances in understanding the pathophysiology and treatment of diabetes and its complications, which could alter the course of this prevalent disorder.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2AnimalsEpidemicsHumansInsulin ResistanceInsulin-Secreting CellsObesity

Identifiers

PMID39059357
PMCPMC11299851

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.