Evidence map›Paper›PMID 39060165›Full record

ReviewThe Journal of pharmacology and experimental therapeutics2024

Analgesic Properties of Next-Generation Modulators of Endocannabinoid Signaling: Leveraging Modern Tools for the Development of Novel Therapeutics.

Simar Singh, Kaylin J Ellioff, Michael R Bruchas, Benjamin B Land, Nephi Stella

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of pharmacology and experimental therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Pro- But Not Antinociceptive Effects of Cannabidiol Depend on Trpa1b in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Simar SinghDepartments of Pharmacology (S.S., K.J.E., M.R.B., B.B.L., N.S.), Anesthesiology and Pain Medicine (M.R.B.), and Psychiatry and Behavioral Sciences (N.S.), and Center of Excellence in Neuroscience of Addiction, Pain, and Emotion (S.S., K.J.E., M.R.B., B.B.L., N.S.), University of Washington, Seattle, Washington.ORCID 0000-0001-5785-8292
Kaylin J EllioffDepartments of Pharmacology (S.S., K.J.E., M.R.B., B.B.L., N.S.), Anesthesiology and Pain Medicine (M.R.B.), and Psychiatry and Behavioral Sciences (N.S.), and Center of Excellence in Neuroscience of Addiction, Pain, and Emotion (S.S., K.J.E., M.R.B., B.B.L., N.S.), University of Washington, Seattle, Washington.
Michael R BruchasDepartments of Pharmacology (S.S., K.J.E., M.R.B., B.B.L., N.S.), Anesthesiology and Pain Medicine (M.R.B.), and Psychiatry and Behavioral Sciences (N.S.), and Center of Excellence in Neuroscience of Addiction, Pain, and Emotion (S.S., K.J.E., M.R.B., B.B.L., N.S.), University of Washington, Seattle, Washington.
Benjamin B LandDepartments of Pharmacology (S.S., K.J.E., M.R.B., B.B.L., N.S.), Anesthesiology and Pain Medicine (M.R.B.), and Psychiatry and Behavioral Sciences (N.S.), and Center of Excellence in Neuroscience of Addiction, Pain, and Emotion (S.S., K.J.E., M.R.B., B.B.L., N.S.), University of Washington, Seattle, Washington.
Nephi StellaDepartments of Pharmacology (S.S., K.J.E., M.R.B., B.B.L., N.S.), Anesthesiology and Pain Medicine (M.R.B.), and Psychiatry and Behavioral Sciences (N.S.), and Center of Excellence in Neuroscience of Addiction, Pain, and Emotion (S.S., K.J.E., M.R.B., B.B.L., N.S.), University of Washington, Seattle, Washington nstella@uw.edu.

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0M
Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
TRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8M
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER37DA033396 · NIDA · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2018 to 2026
$3.8M
Cannabidiol and terpenoid interactions in amygdalar regulation of pain statesR01AT011524 · NCCIH · UNIVERSITY OF WASHINGTON · PI Benjamin Land · 2022 to 2026
$2.1M
DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCER01DA033396 · NIDA · WASHINGTON UNIVERSITY · PI BRUCHAS, MICHAEL R. · 2013 to 2017
$1.9M
Molecular mechanism of ABHD6 enzymatic activity in neuronsR21NS118130 · NINDS · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2020 to 2020
$428k
ABHD6 and amphetamine stimulated locomotionR21DA047626 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI, ZWEIFEL, LARRY S · 2019 to 2020
$409k
Investigating the role of THC in mediating pain signaling in the BLAF31DA061576 · NIDA · UNIVERSITY OF WASHINGTON · PI Kaylin Ellioff · 2024 to 2026
$139k
NCCIH NIH HHS R01 AT011524NIDA NIH HHS F31 DA061576NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA033396NIDA NIH HHS R21 DA047626NIDA NIH HHS R37 DA033396NIDA NIH HHS T32 DA007278NIGMS NIH HHS T32 GM007750NINDS NIH HHS R21 NS118130
6 · The paper itself

Abstract

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and

Indexed as

AnalgesicsEndocannabinoidsPainSignal TransductionAnimalsCannabidiolCannabinoidsDrug DevelopmentHumansMonoacylglycerol LipasesABHD6 protein, humanAnalgesicsCannabidiolCannabinoidsEndocannabinoidsMonoacylglycerol Lipases

Identifiers

PMID39060165
PMCPMC11493443

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.