Evidence map›Paper›PMID 39061535›Full record

ArticleAnimals : an open access journal from MDPI2024

Effects of Sea-Buckthorn Flavonoids on Growth Performance, Serum Inflammation, Intestinal Barrier and Microbiota in LPS-Challenged Broilers.

Kexin Zhi, Fanwen Gong, Lele Chen, Zezheng Li, Xiang Li, Huadi Mei, Chenxing Fu, Yurong Zhao, Zhuying Liu, Jianhua He

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mechanisms ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Article
  5. Challenges in Poultry Production Systems and Nutritional Interventions.Animals : an open access journal from MDPI · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kexin ZhiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Fanwen GongCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Lele ChenCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Zezheng LiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Xiang LiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Huadi MeiCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Chenxing FuCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yurong ZhaoCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-2565-0670
Zhuying LiuCollege of Animal Science and Technology, Hunan Biological and Electromechanical Polytechnic, Changsha 410128, China.ORCID 0000-0002-4267-3700
Jianhua HeCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-9289-4405

Funding

National Key R&D Program of China 2023YFD1301200
6 · The paper itself

Abstract

The experiment investigated the effects of sea-buckthorn flavonoids (SF) on lipopolysaccharide (LPS)-challenged broilers. A total of 288 one-day-old male broilers were randomly assigned to 4 groups, with 6 replicates of 12 broilers each. The experiment lasted for 20 days. The diet included two levels of SF (0 or 1000 mg/kg) and broilers intraperitoneally injected with 500 μg/kg LPS on 16, 18, and 20 days, or an equal amount of saline. LPS challenge decreased final body weight, average daily gain, and average daily feed intake, increased feed-to-gain ratio, and elevated serum IL-1β, IL-2, TNF-α, D-LA, and endotoxin levels. Moreover, it resulted in a reduction in the IL-10 level. LPS impaired the intestinal morphology of the duodenum, jejunum, and ileum, down-regulated the mRNA relative expression of Occludin, ZO-1, and MUC-2 in the jejunum mucosa, up-regulated the mRNA relative expression of TLR4, MyD88, NF-κB, and IL-1β, and increased the relative abundance of

Indexed as

broilersinflammationintestinal healthlipopolysaccharidesea-buckthorn flavone

Identifiers

PMID39061535
PMCPMC11274335

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.