Evidence map›Paper›PMID 39062083›Full record

ArticleBiomedicines2024

Design of Alginate/Gelatin Hydrogels for Biomedical Applications: Fine-Tuning Osteogenesis in Dental Pulp Stem Cells While Preserving Other Cell Behaviors.

Zied Ferjaoui, Roberto López-Muñoz, Soheil Akbari, Fatiha Chandad, Diego Mantovani, Mahmoud Rouabhia, Roberto D Fanganiello

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zied FerjaouiOral Ecology Research Group (GREB), Faculté de Médecine Dentaire, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-2656-2314
Roberto López-MuñozLaboratory for Biomaterials and Bioengineering, (CRC-Tier I), Department of Min-Met-Materials Eng and Regenerative Medicine, CHU de Quebec, Laval University, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0001-7095-1133
Soheil AkbariDépartement de Génie Chimique, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-8642-1679
Fatiha ChandadOral Ecology Research Group (GREB), Faculté de Médecine Dentaire, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-4415-0751
Diego MantovaniLaboratory for Biomaterials and Bioengineering, (CRC-Tier I), Department of Min-Met-Materials Eng and Regenerative Medicine, CHU de Quebec, Laval University, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0001-9672-895X
Mahmoud RouabhiaOral Ecology Research Group (GREB), Faculté de Médecine Dentaire, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0003-2205-8281
Roberto D FanganielloOral Ecology Research Group (GREB), Faculté de Médecine Dentaire, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-5355-255X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alginate/gelatin (Alg-Gel) hydrogels have been used experimentally, associated with mesenchymal stromal/stem cells (MSCs), to guide bone tissue formation. One of the main challenges for clinical application is optimizing Alg-Gel stiffness to guide osteogenesis. In this study, we investigated how Alg-Gel stiffness could modulate the dental pulp stem cell (DPSC) attachment, morphology, proliferation, and osteogenic differentiation, identifying the optimal conditions to uncouple osteogenesis from the other cell behaviors. An array of Alg-Gel hydrogels was prepared by casting different percentages of alginate and gelatin cross-linked with 2% CaCl

Indexed as

alginateDPSCsgelatinhydrogelosteogenic differentiationstiffness

Identifiers

PMID39062083
PMCPMC11274465

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.