Evidence map›Paper›PMID 39062557›Full record

ArticleBiomolecules2024

Zinc Protects against Swine Barn Dust-Induced Cilia Slowing.

Christopher D Bauer, Deanna D Mosley, Derrick R Samuelson, Jill A Poole, Deandra R Smith, Daren L Knoell, Todd A Wyatt

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher D BauerDepartment of Internal Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198, USA.
Deanna D MosleyDepartment of Internal Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198, USA.
Derrick R SamuelsonDepartment of Internal Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-5356-1413
Jill A PooleDepartment of Internal Medicine, Division of Allergy & Immunology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-6236-2563
Deandra R SmithDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Daren L KnoellDepartment of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-9977-2857
Todd A WyattDepartment of Internal Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, University of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-9273-6730

Funding

Surveillance of Agricultural Injuries in the Central States RegionsU54OH010162 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RAUTIAINEN, RISTO HEIKKI · 2011 to 2025
$23.6M
The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and HeartP50AA030407 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Todd A Wyatt · 2023 to 2026
$7.9M
Gut bacterial metallophores in the development and severity of inflammatory bowel diseaseR01DK131990 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Derrick R Samuelson · 2022 to 2026
$3.3M
Resolving Occupational Exposure-Induced Lung DiseaseR01OH012045 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2021 to 2024
$2.3M
Defective Zn Homeostasis impairs host defense against pneumococcal pneumoniaR01HL156952 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KNOELL, DAREN LEE · 2022 to 2025
$1.5M
Reactive aldehydes and alcohol misuse in lung infectionsI01BX005886 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2023 to 2025
–
BLR&D Research Career Scientist ApplicationIK6BX005962 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2022 to 2025
–
BLRD VA I01 BX005886BLRD VA IK6 BX005962NHLBI NIH HHS R01 HL156952NIAAA NIH HHS P50 AA030407NIDDK NIH HHS R01 DK131990NIOSH CDC HHS R01 OH012045NIOSH CDC HHS U54 OH010162United States Department of Defense PR200793
6 · The paper itself

Abstract

Agricultural workers exposed to organic dust from swine concentrated animal feeding operations (CAFOs) have increased chances of contracting chronic lung disease. Mucociliary clearance represents a first line of defense against inhaled dusts, but organic dust extracts (ODEs) from swine barns cause cilia slowing, leading to decreased bacterial clearance and increased lung inflammation. Because nutritional zinc deficiency is associated with chronic lung disease, we examined the role of zinc supplementation in ODE-mediated cilia slowing. Ciliated mouse tracheal epithelial cells were pretreated with 0-10 µg/mL ZinPro

Indexed as

CiliaDustProtein Kinase C-epsilonZincAnimalsEpithelial CellsMiceSwineTracheaDustProtein Kinase C-epsilonZinccilialungorganic dustzinc

Identifiers

PMID39062557
PMCPMC11274422

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.