Evidence map›Paper›PMID 39062571›Full record

ReviewBiomolecules2024

Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine.

Benoit Coulombe, Alexandra Chapleau, Julia Macintosh, Thomas M Durcan, Christian Poitras, Yena A Moursli, Denis Faubert, Maxime Pinard, Geneviève Bernard

Abstract readReview
In one paragraph

Review in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benoit CoulombeTranslational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.ORCID 0000-0003-1702-0692
Alexandra ChapleauDepartment of Neurology and Neurosurgery, Pediatrics and Human Genetics, McGill University, Montréal, QC H9X 3V9, Canada.ORCID 0000-0002-4741-1355
Julia MacintoshDepartment of Neurology and Neurosurgery, Pediatrics and Human Genetics, McGill University, Montréal, QC H9X 3V9, Canada.
Thomas M DurcanThe Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montréal, QC H9X 3V9, Canada.ORCID 0000-0003-3942-1956
Christian PoitrasTranslational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.ORCID 0000-0001-6444-7600
Yena A MoursliTranslational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Denis FaubertMass Spectrometry and Proteomics Platform, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.ORCID 0000-0001-9550-4495
Maxime PinardTranslational Proteomics Laboratory, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada.
Geneviève BernardDepartment of Neurology and Neurosurgery, Pediatrics and Human Genetics, McGill University, Montréal, QC H9X 3V9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-based interception and precision medicine is a novel approach aimed at improving healthcare through the early detection and treatment of diseased cells. Here, we describe our recent progress towards developing cell-based interception and precision medicine to detect, understand, and advance the development of novel therapeutic approaches through a single-cell omics and drug screening platform, as part of a multi-laboratory collaborative effort, for a group of neurodegenerative disorders named leukodystrophies. Our strategy aims at the identification of diseased cells as early as possible to intercept progression of the disease prior to severe clinical impairment and irreversible tissue damage.

Indexed as

Precision MedicineAnimalsHumansSingle-Cell Analysiscell-based interception and precision medicineinduced pluripotent stem cellsleukodystrophyPOLR3-related leukodystrophy (POLR3-HLD)proteomicsSCoPE2-MSsingle-cell technologies

Identifiers

PMID39062571
PMCPMC11274857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.