Evidence map›Paper›PMID 39062833›Full record

ArticleInternational journal of molecular sciences2024

A Single Injection of ADRCs Does Not Prevent AAA Formation in Rats in a Randomized Blinded Design.

Egle Kavaliunaite, Pratibha Dhumale, Charlotte Harken Jensen, Søren P Sheikh, Jes S Lindholt, Jane Stubbe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Egle KavaliunaiteCardiovascular and Renal Research Unit, Institute for Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark.
Pratibha DhumaleDepartment of Clinical Research, University of Southern Denmark (SDU), 5230 Odense M, Denmark.
Charlotte Harken JensenDepartment of Clinical Research, University of Southern Denmark (SDU), 5230 Odense M, Denmark.ORCID 0000-0001-9683-8761
Søren P SheikhOpen Patient Data Explorative Network, Institute of Clinical Research, Odense University Hospital (OUH), 5000 Odense C, Denmark.
Jes S LindholtDepartment of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital (OUH), 5000 Odense C, Denmark.ORCID 0000-0001-9536-4488
Jane StubbeCardiovascular and Renal Research Unit, Institute for Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark.ORCID 0000-0002-2703-453X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a pressing need for alternative medical treatments for abdominal aortic aneurysms (AAAs). Mesenchymal regenerative cells derived from adipose tissue (ADRCs) have shown potential in modulating the inflammation and immune responses that drive AAA progression. We hypothesized that ADRCs could reduce inflammation and preserve vascular integrity, potentially slowing the progression of AAA. In our study, subcutaneous adipose tissue was harvested from male Sprague Dawley rats, from which ADRCs were isolated. AAA was induced in these rats using intraluminal porcine pancreatic elastase, followed by intravenous administration of either ADRCs (10

Indexed as

Adipose TissueAortic Aneurysm, AbdominalRats, Sprague-DawleyAnimalsAorta, AbdominalDisease Models, AnimalMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRatsabdominal aortic aneurysmregenerative medicinestem cells

Identifiers

PMID39062833
PMCPMC11276694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.