Evidence map›Paper›PMID 39062857›Full record

ArticleInternational journal of molecular sciences2024

Inhibiting miR-618 Promotes Keratinocytes Proliferation and Migration to Enhance Wound Healing in Mice.

Lingling Wu, Wenjun Fu, Yiyang Cao, Shuo Zhao, Yuchen Zhang, Xiaonan Li, Naijun Dong, Wenxin Qi, Rabia Malik, Jiao Wang and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingling WuSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Wenjun FuSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Yiyang CaoSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Shuo ZhaoSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Yuchen ZhangSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Xiaonan LiSchool of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID 0009-0006-6441-8942
Naijun DongSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Wenxin QiSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Rabia MalikSchool of Life Sciences, Shanghai University, Shanghai 200444, China.
Jiao WangSchool of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID 0000-0001-9875-5425
Robert Chunhua ZhaoSchool of Life Sciences, Shanghai University, Shanghai 200444, China.

Funding

Basic Research Program of Shanghai 20JC1412200National Key Research and Development Program of China 2020YFA0113000
6 · The paper itself

Abstract

The delay in wound healing caused by chronic wounds or pathological scars is a pressing issue in clinical practice, imposing significant economic and psychological burdens on patients. In particular, with the aging of the population and the increasing incidence of diseases such as diabetes, impaired wound healing is one of the growing health problems. MicroRNA (miRNA) plays a crucial role in wound healing and regulates various biological processes. Our results show that miR-618 was significantly upregulated during the inflammatory phase of wound healing.Subsequently, miR-618 promotes the secretion of pro-inflammatory cytokines and regulates the proliferation and migration of keratinocytes. Mechanistically, miR-618 binds to the target gene-

Indexed as

Cell MovementCell ProliferationEpithelial-Mesenchymal TransitionKeratinocytesMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionWound HealingAnimalsAntagomirsHumansMiceAntagomirsMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktepithelial–mesenchymal transitionmiR–618wound healing

Identifiers

PMID39062857
PMCPMC11277496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.