Evidence map›Paper›PMID 39062981›Full record

ArticleInternational journal of molecular sciences2024

Jorge Melones-Herrero, Patricia Delgado-Aliseda, Sofía Figueiras, Javier Velázquez-Gutiérrez, Adoración Gomez Quiroga, Carmela Calés, Isabel Sánchez-Pérez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jorge Melones-HerreroDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.ORCID 0000-0001-9194-1815
Patricia Delgado-AlisedaDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.ORCID 0009-0003-4066-8611
Sofía FigueirasDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.ORCID 0000-0002-8982-1512
Javier Velázquez-GutiérrezDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.ORCID 0000-0002-5995-2677
Adoración Gomez QuirogaDepartment of Inorganic Chemistry, School of Sciences, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0002-9261-9542
Carmela CalésDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.
Isabel Sánchez-PérezDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28029 Madrid, Spain.ORCID 0000-0002-4829-201X

Funding

Ministerio de Ciencia, Innovación y Universidades PID2019-106220RB100Ministerio de Ciencia, Innovación y Universidades PID2022-137373OB-I00
6 · The paper itself

Abstract

Gastric cancer prognosis is still notably poor despite efforts made to improve diagnosis and treatment of the disease. Chemotherapy based on platinum agents is generally used, regardless of the fact that drug toxicity leads to limited clinical efficacy. In order to overcome these problems, our group has been working on the synthesis and study of trans platinum (II) complexes. Here, we explore the potential use of two phosphine-based agents with the general formula

Indexed as

ApoptosisEndoplasmic ReticulumEndoplasmic Reticulum StressMitochondriaReactive Oxygen SpeciesStomach NeoplasmsAntineoplastic AgentsCell Line, TumorCell SurvivalDNA DamageHumansMembrane Potential, MitochondrialOrganoplatinum CompoundsPhosphinesUnfolded Protein ResponseAntineoplastic AgentsOrganoplatinum CompoundsPhosphinesReactive Oxygen SpeciesapoptosisER stressgastric cancermitochondriaphosphineplatinum complexes

Identifiers

PMID39062981
PMCPMC11276749

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.