ReviewInternational journal of molecular sciences2024
Behind the Curtain of Abnormal Placentation in Pre-Eclampsia: From Molecular Mechanisms to Histological Hallmarks.
Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Natural killer cells in preeclampsia: an overview of current research.Frontiers in immunology · 2026Pooled it
- Correlations of Free Beta-Human Chorionic Gonadotropin/Pregnancy-Associated Plasma Protein A Ratio, Pregnancy Characteristics, and Placental Pathology in Fetal Growth Restriction.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Gestational-Age Clustering of Recurrent Placental Abruption: A Multicenter Retrospective Descriptive Study.Journal of clinical medicine · 2026Article
- Role of Factors in Embryo Implantation and Placental Development.Biomedicines · 2026Article
- Intraoperative Transvaginal Ultrasonographic Evaluation for Placenta Accreta Spectrum in Placenta Previa: A Retrospective Observational Study.The journal of obstetrics and gynaecology research · 2026Observational
- The human placenta development and anatomy.Archives of gynecology and obstetrics · 2026Review
- Transcription factor IRF1 modulates HDAC1 and PANoptosis to regulate preeclampsia progression.Biology direct · 2026Article
- Correlations Between Pregnancy-Associated Plasma Protein A Levels and Pregnancy Characteristics, Placental Volume, Vascularization, and Histopathology.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia.Journal of molecular histology · 2026Article
- Serum osteoprotegerin levels and their association with preeclampsia severity: a case-control study.BMC pregnancy and childbirth · 2026Article
- Regulatory T cells in pregnancy disorders: a multi-dimensional framework for biomarkers and therapeutic strategies.Frontiers in immunology · 2026Review
- The Role of Epigenetics in Preeclampsia.Advances in experimental medicine and biology · 2026Review
- Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.Molecular nutrition & food research · 2025Review
- Review
- Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions.Medical sciences (Basel, Switzerland) · 2025Article
- Molecular Insights into Human Placentation: From Villous Morphogenesis to Pathological Pathways and Translational Biomarkers.International journal of molecular sciences · 2025Review
- The Role of Mitochondrial Dysfunction and Oxidative Stress in Women's Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia.International journal of molecular sciences · 2025Review
- Exploring the Impact of First Trimester Elevated Lipoprotein(a) Levels on Preeclampsia, Preterm Delivery, and Fetal Growth Restriction.Journal of clinical medicine · 2025Article
- The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia.Antioxidants (Basel, Switzerland) · 2025Review
- The Association of Assisted Reproductive Technology with Placental and Umbilical Abnormalities.Journal of personalized medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful human pregnancy needs several highly controlled steps to guarantee an oocyte's fertilization, the embryo's pre-implantation development, and its subsequent implantation into the uterine wall. The subsequent placenta development ensures adequate fetal nutrition and oxygenation, with the trophoblast being the first cell lineage to differentiate during this process. The placenta sustains the growth of the fetus by providing it with oxygen and nutrients and removing waste products. It is not surprising that issues with the early development of the placenta can lead to common pregnancy disorders, such as recurrent miscarriage, fetal growth restriction, pre-eclampsia, and stillbirth. Understanding the normal development of the human placenta is essential for recognizing and contextualizing any pathological aberrations that may occur. The effects of these issues may not become apparent until later in pregnancy, during the mid or advanced stages. This review discusses the process of the embryo implantation phase, the molecular mechanisms involved, and the abnormalities in those mechanisms that are thought to contribute to the development of pre-eclampsia. The review also covers the histological hallmarks of pre-eclampsia as found during the examination of placental tissue from pre-eclampsia patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.