Evidence map›Paper›PMID 39063146›Full record

ArticleInternational journal of molecular sciences2024

The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring.

Wojciech Kuban, Anna Haduch, Ewa Bromek, Agnieszka Basińska-Ziobroń, Kinga Gawlińska, Dawid Gawliński, Małgorzata Filip, Władysława A Daniel

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wojciech KubanDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-0401-1714
Anna HaduchDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-3925-3828
Ewa BromekDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.
Agnieszka Basińska-ZiobrońDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.
Kinga GawlińskaDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0001-7015-154X
Dawid GawlińskiDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-9376-0564
Małgorzata FilipDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-4321-7942
Władysława A DanielDepartment of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland.ORCID 0000-0002-1226-1721

Funding

National Science Foundation 2016/21/B/NZ4/0020
6 · The paper itself

Abstract

Cytochrome P450 2D (CYP2D) is important in psychopharmacology as it is engaged in the metabolism of drugs, neurosteroids and neurotransmitters. An unbalanced maternal diet during pregnancy and lactation can cause neurodevelopmental abnormalities and increases the offspring's predisposition to neuropsychiatric diseases. The aim of the present study was to evaluate the effect of maternal modified types of diet: a high-fat diet (HFD) and high-carbohydrate diet (HCD) during pregnancy and lactation on CYP2D in the liver and brain of male offspring at 28 (adolescent) or 63 postnatal days (young adult). The CYP2D activity and protein level were measured in the liver microsomes and the levels of mRNAs of

Indexed as

BrainDiet, High-FatLactationLiverPrenatal Exposure Delayed EffectsAnimalsAryl Hydrocarbon HydroxylasesCytochrome P-450 Enzyme SystemCytochrome P450 Family 2FemaleMaleMicrosomes, LiverPregnancyRatsRats, WistarRNA, MessengerAryl Hydrocarbon HydroxylasesCyp2d1 protein, ratCyp2d2 protein, ratCyp2d4 protein, ratCytochrome P-450 Enzyme SystemCytochrome P450 Family 2RNA, Messengerbraincytochrome P450 2D (CYP2D)high-fat and high-carbohydrate dietlivermale offspringmaternal diet

Identifiers

PMID39063146
PMCPMC11276948

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.