Evidence map›Paper›PMID 39063168›Full record

ReviewInternational journal of molecular sciences2024

Revisiting Epigenetics Fundamentals and Its Biomedical Implications.

Thuluz Meza-Menchaca, Arnulfo Albores-Medina, Alma Jaqueline Heredia-Mendez, Eliel Ruíz-May, Jorge Ricaño-Rodríguez, Verónica Gallegos-García, Adriana Esquivel, Giancarlo Vettoretti-Maldonado, Alma D Campos-Parra

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thuluz Meza-MenchacaLaboratorio de Investigación en Ciencias Médico-Biológicas, Facultad de Medicina, Universidad Veracruzana, Médicos y Odontólogos s/n, Col. Unidad del Bosque, Xalapa 91010, Mexico.
Arnulfo Albores-MedinaDepartamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 07360, Mexico.
Alma Jaqueline Heredia-MendezLaboratorio de Investigación en Ciencias Médico-Biológicas, Facultad de Medicina, Universidad Veracruzana, Médicos y Odontólogos s/n, Col. Unidad del Bosque, Xalapa 91010, Mexico.
Eliel Ruíz-MayRed de Estudios Moleculares Avanzados, Cluster BioMimic®, Instituto de Ecología A. C., Carretera Antigua a Coatepec 351, Congregación el Haya, Xalapa 91073, Mexico.ORCID 0000-0003-1416-4973
Jorge Ricaño-RodríguezCentro de Eco-Alfabetización y Diálogo de Saberes, Universidad Veracruzana, Zona Universitaria, Xalapa 91090, Mexico.ORCID 0000-0001-6297-0748
Verónica Gallegos-GarcíaFacultad de Enfermería y Nutrición, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, Mexico.
Adriana EsquivelLaboratorio de Investigación en Ciencias Médico-Biológicas, Facultad de Medicina, Universidad Veracruzana, Médicos y Odontólogos s/n, Col. Unidad del Bosque, Xalapa 91010, Mexico.
Giancarlo Vettoretti-MaldonadoLaboratorio de Investigación en Ciencias Médico-Biológicas, Facultad de Medicina, Universidad Veracruzana, Médicos y Odontólogos s/n, Col. Unidad del Bosque, Xalapa 91010, Mexico.
Alma D Campos-ParraInstituto de Salud Pública, Universidad Veracruzana, Xalapa 91190, Mexico.ORCID 0000-0003-1750-5171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In light of the post-genomic era, epigenetics brings about an opportunity to better understand how the molecular machinery works and is led by a complex dynamic set of mechanisms, often intricate and complementary in many aspects. In particular, epigenetics links developmental biology and genetics, as well as many other areas of knowledge. The present work highlights substantial scopes and relevant discoveries related to the development of the term from its first notions. To our understanding, the concept of epigenetics needs to be revisited, as it is one of the most relevant and multifaceted terms in human knowledge. To redirect future novel experimental or theoretical efforts, it is crucial to compile all significant issues that could impact human and ecological benefit in the most precise and accurate manner. In this paper, the reader can find one of the widest compilations of the landmarks and epistemic considerations of the knowledge of epigenetics across the history of biology from the earliest epigenetic formulation to genetic determinism until the present. In the present work, we link the current body of knowledge and earlier pre-genomic concepts in order to propose a new definition of epigenetics that is faithful to its regulatory nature.

Indexed as

Epigenesis, GeneticEpigenomicsAnimalsDNA MethylationHumansbiomedicineepigeneticsepistemologyomics

Identifiers

PMID39063168
PMCPMC11276703

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.