Evidence map›Paper›PMID 39063170›Full record

ArticleInternational journal of molecular sciences2024

Novel Piperazine Derivatives of Vindoline as Anticancer Agents.

Bernadett Zsoldos, Nóra Nagy, Viktória Donkó-Tóth, Péter Keglevich, Márton Weber, Miklós Dékány, Andrea Nehr-Majoros, Éva Szőke, Zsuzsanna Helyes, László Hazai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernadett ZsoldosDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Nóra NagyDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Viktória Donkó-TóthDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Péter KeglevichDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.
Márton WeberSpectroscopic Research Department, Gedeon Richter Plc., P.O. Box 27, H-1475 Budapest, Hungary.
Miklós DékánySpectroscopic Research Department, Gedeon Richter Plc., P.O. Box 27, H-1475 Budapest, Hungary.ORCID 0000-0001-8032-2998
Andrea Nehr-MajorosDepartment of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
Éva SzőkeDepartment of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
Zsuzsanna HelyesDepartment of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
László HazaiDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel vindoline-piperazine conjugates were synthesized by coupling 6

Indexed as

Antineoplastic AgentsCell ProliferationCricetulusPiperazinePiperazinesAnimalsCell Line, TumorCell SurvivalCHO CellsDrug Screening Assays, AntitumorHumansStructure-Activity RelationshipVinblastineAntineoplastic AgentsPiperazinePiperazinesVinblastinevindolineantitumor effectcell viabilitylinkersN-substituted piperazinessynthesisvindoline

Identifiers

PMID39063170
PMCPMC11277489

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.