Evidence map›Paper›PMID 39063181›Full record

ArticleInternational journal of molecular sciences2024

Effect of Acetylsalicylic Acid on Biological Properties of Novel Cement Based on Calcium Phosphate Doped with Ions of Strontium, Copper, and Zinc.

Tamara Vlajić Tovilović, Sanja Petrović, Miloš Lazarević, Aleksandar Pavić, Nikola Plačkić, Aleksa Milovanović, Miloš Milošević, Vesna Miletic, Djordje Veljović, Milena Radunović

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tamara Vlajić TovilovićSchool of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0002-3606-9646
Sanja PetrovićSchool of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0002-4847-0891
Miloš LazarevićSchool of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0003-1330-5332
Aleksandar PavićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11 000 Belgrade, Serbia.
Nikola PlačkićInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0009-0005-3466-6841
Aleksa MilovanovićFaculty of Mechanical Engineering, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0003-4668-8800
Miloš MiloševićFaculty of Mechanical Engineering, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0002-2418-1032
Vesna MileticFaculty of Medicine and Health, Sydney Dental School, University of Sydney, Surry Hills, NSW 2010, Australia.ORCID 0000-0001-9892-1323
Djordje VeljovićFaculty of Technology and Metallurgy, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0001-6370-7167
Milena RadunovićSchool of Dental Medicine, University of Belgrade, 11 000 Belgrade, Serbia.ORCID 0000-0003-3507-1186

Funding

Ministry of Science, Technological Development and Innovation, Republic of Serbia 451-03-65/2024-03/200135Ministry of Science, Technological Development and Innovation, Republic of Serbia 451-03-66/2024-03/200042Ministry of Science, Technological Development and Innovation, Republic of Serbia 451-03-9/2021-14/200129
6 · The paper itself

Abstract

This study aimed to compare the biological properties of newly synthesized cements based on calcium phosphate with a commercially used cement, mineral trioxide aggregate (MTA). Strontium (Sr)-, Copper (Cu)-, and Zinc (Zn)-doped hydroxyapatite (miHAp) powder was obtained through hydrothermal synthesis and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive X-ray spectrometry (EDX). Calcium phosphate cement (CPC) was produced by mixing miHAp powder with a 20 wt.% citric acid solution, followed by the assessment of its compressive strength, setting time, and in vitro bioactivity. Acetylsalicylic acid (ASA) was added to the CPC, resulting in CPCA. Biological tests were conducted on CPC, CPCA, and MTA. The biocompatibility of the cement extracts was evaluated in vitro using human dental pulp stem cells (hDPSCs) and in vivo using a zebrafish model. Antibiofilm and antimicrobial effect (quantified by CFUs/mL) were assessed against

Indexed as

AspirinCalcium PhosphatesCopperStrontiumZincAnimalsBiocompatible MaterialsBiofilmsCell ProliferationDental CementsDental PulpHumansMaterials TestingStem CellsStreptococcus mutansX-Ray DiffractionAspirinBiocompatible Materialscalcium phosphateCalcium PhosphatesCopperDental CementsStrontiumZincantibiofilmcalcium phosphatedental pulp stem cellshydroxyapatitezebrafish

Identifiers

PMID39063181
PMCPMC11276672

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.