Mechanical Properties, Drug Release, Biocompatibility, and Antibacterial Activities of Modified Emulsified Gelatin Microsphere Loaded with Gentamicin Composite Calcium Phosphate Bone Cement In Vitro.

Ming-Hsien Hu, Bo-Sin Shih, Shih-Ming Liu, Ssu-Meng Huang, Chia-Ling Ko, Wen-Cheng Chen

Abstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ming-Hsien HuOrthopedic Department, Show Chwan Memorial Hospital, Changhua 500, Taiwan.

Bo-Sin ShihAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407, Taiwan.

Shih-Ming LiuAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407, Taiwan.

Ssu-Meng HuangAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407, Taiwan.

Chia-Ling KoAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407, Taiwan.

Wen-Cheng ChenAdvanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 407, Taiwan.ORCID 0000-0002-5581-9991

Funding

Ministry of Science and Technology, Taiwan MOST 110-2221-E-035-013, 109-2622-E-035-043, 109-2622-E-035-014-CC2Show Chwan Memorial Hospital SRD109016Southern Taiwan Science Park Bureau, National Science and Technology Council 112CB-1-02

6 · The paper itself

Abstract

Bone defects are commonly addressed with bone graft substitutes; however, surgical procedures, particularly for open and complex fractures, may pose a risk of infection. As such, a course of antibiotics combined with a drug carrier is often administered to mitigate potential exacerbations. This study involved the preparation and modification of emulsified (Em) crosslinking-gelatin (gel) microspheres (m-Em) to reduce their toxicity. The antibiotic gentamicin was impregnated into gel microspheres (m-EmG), which were incorporated into calcium phosphate bone cement (CPC). The study investigated the effects of m-EmG@CPC on antibacterial activity, mechanical properties, biocompatibility, and proliferation and mineralization of mouse progenitor osteoblasts (D1 cells). The average size of the gel microspheres ranged from 22.5 to 16.1 μm, with no significant difference between the groups (

Indexed as

antibioticcalcium phosphate bone cement (CPC)compositeemulsificationhydrogelsin vitromicrospheres

Identifiers

PMID39063872

DOI10.3390/ma17143578

PMCPMC11279002

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.