Evidence map›Paper›PMID 39065553›Full record

ArticlePharmaceutics2024

Iron-Reduced Graphene Oxide Core-Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light.

Orlando Donoso-González, Ana L Riveros, José F Marco, Diego Venegas-Yazigi, Verónica Paredes-García, Camila F Olguín, Cristina Mayorga-Lobos, Lorena Lobos-González, Felipe Franco-Campos, Joseph Wang and 4 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Orlando Donoso-GonzálezDepartamento Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.ORCID 0000-0002-9614-7781
Ana L RiverosDepartamento Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.
José F MarcoInstituto de Química Física Blas Cabrera, Consejo Superior de Investigaciones Científicas (CSIC), Serrano 119, 28006 Madrid, Spain.ORCID 0000-0002-5147-1449
Diego Venegas-YazigiDepartamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, Libertador Bernardo O'Higgins #3363, Estación Central, Santiago 9170022, Chile.ORCID 0000-0001-7816-2841
Verónica Paredes-GarcíaCentro para el Desarrollo de La Nanociencia y la Nanotecnología (CEDENNA), Universidad de Santiago de Chile, Libertador Bernardo O'Higgins #3363, Estación Central, Santiago 9170022, Chile.ORCID 0000-0002-7537-7430
Camila F OlguínEscuela de Medicina, Universidad de Talca, Talca 3460000, Chile.
Cristina Mayorga-LobosAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.
Lorena Lobos-GonzálezCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380492, Chile.ORCID 0000-0002-4957-9864
Felipe Franco-CamposResearch Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox), Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, 46100 Valencia, Spain.ORCID 0009-0002-7850-6186
Joseph WangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA 92093, USA.
Marcelo J KoganDepartamento Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.ORCID 0000-0003-0608-5087
Soledad BolloDepartamento Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.ORCID 0000-0003-0868-4294
Claudia YañezCentro de Investigación de Procesos Redox, CIPRex, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.ORCID 0000-0003-4531-0742
Daniela F BáezAdvanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Sergio Livingstone #1007, Independencia, Santiago 8380492, Chile.ORCID 0000-0002-9663-8521

Funding

Agencia Nacional de Investigación y Desarrollo 11200416Agencia Nacional de Investigación y Desarrollo FOVI220173
6 · The paper itself

Abstract

Core-shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core-shell micromotor that combines magnetic and photothermal properties. It is synthesized via the template-assisted electrodeposition of iron (Fe) and reduced graphene oxide (rGO) on a microtubular pore-shaped membrane. The resulting Fe-rGO micromotor consists of a core of oval-shaped zero-valent iron nanoparticles with large magnetization. At the same time, the outer layer has a uniform reduced graphene oxide (rGO) topography. Combined, these Fe-rGO core-shell micromotors respond to magnetic forces and near-infrared (NIR) light (1064 nm), achieving a remarkable photothermal conversion efficiency of 78% at a concentration of 434 µg mL

Indexed as

cancercore–shell micromotorsmagnetic guidancephotothermal effectphotothermal therapyreduced graphene oxide

Identifiers

PMID39065553
PMCPMC11279713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.