Evidence map›Paper›PMID 39069599›Full record

Trial reportDiabetologia2024

Assessing the influence of insulin type (ultra-rapid vs rapid insulin) and exercise timing on postprandial exercise-induced hypoglycaemia risk in individuals with type 1 diabetes: a randomised controlled trial.

Joséphine Molveau, Étienne Myette-Côté, Sémah Tagougui, Nadine Taleb, Roxane St-Amand, Corinne Suppère, Valérie Bourdeau, Elsa Heyman, Rémi Rabasa-Lhoret

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03659799 (A Double-blind, Randomized, Cross-over Study to Compare the Impact of Rapid-acting Insulin Aspart and Faster Acting Aspart), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03659799 phase4completednot on this map

A Double-blind, Randomized, Cross-over Study to Compare the Impact of Rapid-acting Insulin Aspart and Faster Acting Aspart (FiAsp) on Glucose Excursion During Postprandial Exercise in Adults With Type 1 Diabetes

TypeinterventionalSponsorInstitut de Recherches Cliniques de MontrealRan2019 to 2023Enrolled40ConditionsType 1 Diabetes MellitusArmsInsulin FiAsp, Insulin Aspart, 60-minutes postprandial exercise, 120-minutes postprandial exercise
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joséphine MolveauInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-4005-990X
Étienne Myette-CôtéInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.
Sémah TagouguiULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Université de Lille, Université d'Artois, Université du Littoral Côte d'Opale, Lille, France.
Nadine TalebInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.
Roxane St-AmandInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.
Corinne SuppèreInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.
Valérie BourdeauInstitut de recherches cliniques de Montréal, Montréal, QC, Canada.
Elsa HeymanULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Université de Lille, Université d'Artois, Université du Littoral Côte d'Opale, Lille, France.
Rémi Rabasa-LhoretInstitut de recherches cliniques de Montréal, Montréal, QC, Canada. remi.rabasa-lhoret@ircm.qc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThe relationship between pre-meal insulin type, exercise timing and the risk of postprandial exercise-induced hypoglycaemia in people living with type 1 diabetes is unknown. We aimed to evaluate the effects of exercise timing (60 vs 120 min post meal) and different insulin types (aspart vs ultra-rapid aspart) on hypoglycaemic risk.

methodsThis was a four-way crossover randomised trial including 40 individuals with type 1 diabetes using multiple daily injections (mean HbA

resultsPrior to exercise onset, time spent in hyperglycaemia was lower for EX60min vs EX120min (time >10.0 mmol/l: 56.6% [1.2-100%] vs 78.0% [52.7-97.9%]; p<0.001). The glucose reduction between exercise onset and nadir was less pronounced with EX60min vs EX120min (-3.8±2.7 vs -4.7±2.5 mmol/l; p<0.001). A similar number of hypoglycaemic events occurred during both exercise timings. Blood glucose between exercise onset and nadir decreased less with ultra-rapid aspart compared with aspart (-4.1±2.3 vs -4.4±2.8 mmol/l; p=0.037). While a similar number of hypoglycaemic events during exercise were observed, less post-exercise hypoglycaemia occurred with ultra-rapid aspart (n=0, 0%, vs n=15, 38%; p=0.003). No interactions between insulin types and exercise timings were found. CONCLUSIONS/

interpretationEX60min blunted the pre-exercise glucose increase following breakfast and was associated with a smaller glucose reduction during exercise. Ultra-rapid aspart led to a smaller blood glucose reduction during exercise and might be associated with diminished post-exercise hypoglycaemia.

trial registrationClinicalTrials.gov NCT03659799

fundingThis study was funded by Novo Nordisk Canada.

Indexed as

Blood GlucoseCross-Over StudiesDiabetes Mellitus, Type 1ExerciseHypoglycemiaInsulinPostprandial PeriodAdultFemaleHumansHypoglycemic AgentsInsulin AspartMaleMiddle AgedBlood GlucoseHypoglycemic AgentsInsulinInsulin AspartExercise timingHypoglycaemiaPostprandial exerciseUltra-rapid insulin

Identifiers

PMID39069599

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.