Evidence map›Paper›PMID 39071059›Full record

ArticleACS central science2024

Spatial Visualization of A-to-I Editing in Cells Using Endonuclease V Immunostaining Assay (EndoVIA).

Alexandria L Quillin, Benoît Arnould, Steve D Knutson, Jennifer M Heemstra

Abstract read
In one paragraph

Article in ACS central science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alexandria L QuillinDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID https://orcid.org/0000-0002-9725-2911
Benoît ArnouldDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.
Steve D KnutsonMerck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, United States.
Jennifer M HeemstraDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, United States.ORCID https://orcid.org/0000-0002-7691-8526

Funding

A chemical biology toolbox for RNA post-transcriptional modification and captureR35GM144075 · NIGMS · WASHINGTON UNIVERSITY · PI Jennifer Heemstra · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM144075
6 · The paper itself

Abstract

Adenosine-to-inosine (A-to-I) editing is one of the most widespread post-transcriptional RNA modifications and is catalyzed by adenosine deaminases acting on RNA (ADARs). Varying across tissue types, A-to-I editing is essential for numerous biological functions, and dysregulation leads to autoimmune and neurological disorders, as well as cancer. Recent evidence has also revealed a link between RNA localization and A-to-I editing, yet understanding of the mechanisms underlying this relationship and its biological impact remains limited. Current methods rely primarily on

Identifiers

PMID39071059
PMCPMC11273454

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.