Evidence map›Paper›PMID 39072012›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts.

Seyma Katrinli, Agaz H Wani, Adam X Maihofer, Andrew Ratanatharathorn, Nikolaos P Daskalakis, Janitza Montalvo-Ortiz, Diana L Núñez-Ríos, Anthony S Zannas, Xiang Zhao, Allison E Aiello and 73 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

83 authors.

Seyma KatrinliEmory University, Department of Gynecology and Obstetrics, Atlanta, GA, US.
Agaz H WaniUniversity of South Florida, Genomics Program, College of Public Health, Tampa, FL, US.
Adam X MaihoferUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Andrew RatanatharathornColumbia University Mailmain School of Public Health, Department of Epidemiology, New York, NY, US.
Nikolaos P DaskalakisBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, US.
Janitza Montalvo-OrtizU.S. Department of Veterans Affairs National Center of Posttraumatic Stress Disorder, Clinical Neurosciences Division, West Haven, CT, US.
Diana L Núñez-RíosU.S. Department of Veterans Affairs National Center of Posttraumatic Stress Disorder, Clinical Neurosciences Division, West Haven, CT, US.
Anthony S ZannasUniversity of North Carolina at Chapel Hill, Carolina Stress Initiative, Chapel Hill, NC, US.
Xiang ZhaoBoston University School of Public Health, Department of Biostatistics, Boston, MA, US.
Allison E AielloColumbia University, Robert N Butler Columbia Aging Center, Department of Epidemiology, New York, NY, US.
Allison E Ashley-KochDuke University Medical Center, Duke Molecular Physiology Institute, Durham, NC, US.
Diana AvetyanUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Dewleen G BakerUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Jean C BeckhamDuke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, US.
Marco P BoksBrain Center University Medical Center Utrecht, Department of Psychiatry, Utrecht, UT, NL.
Leslie A BrickAlpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI, US.
Evelyn BrometState University of New York at Stony Brook, Epidemiology Research Group, Stony Brook, NY, US.
Frances A ChampagneThe University of Texas at Austin, Department of Psychology, Austin, TX, US.
Chia-Yen ChenBiogen Inc., Translational Sciences, Cambridge, MA, US.
Shareefa DalvieUniversity of Cape Town, Department of Pathology, Cape Town, Western Province, ZA.
Michelle F DennisDuke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, US.
Segun FatumoMRC/UVRI and London School of Hygiene and Tropical Medicine, The African Computational Genomics (TACG) Research Group, Entebbe, Wakiso, Uganda.
Catherine FortierHarvard Medical School, Department of Psychiatry, Boston, MA, US.
Sandro GaleaBoston University School of Public Health, Boston, MA, US.
Melanie E GarrettDuke University Medical Center, Duke Molecular Physiology Institute, Durham, NC, US.
Elbert GeuzeNetherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht, UT, NL.
Gerald GrantDuke University School of Medicine, Department of Neurosurgery, Durham, NC, US.
Michael A HauserDuke University School of Medicine, Department of Medicine, Durham, NC, US.
Jasmeet P HayesThe Ohio State University, Department of Psychology, Columbus, OH, US.
Sian Mj HemmingsStellenbosch University, Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA.
Bertrand Russel HuberBoston University School of Medicine, Department of Neurology, Boston, MA, US.
Aarti JajooBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, US.
Stefan JansenUniversity of Rwanda, College of Medicine and Health Sciences, Kigali, RW.
Ronald C KesslerHarvard Medical School, Department of Health Care Policy, Boston, MA, US.
Nathan A KimbrelDuke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, US.
Anthony P KingThe Ohio State University, College of Medicine, Institute for Behavioral Medicine Research, Columbus, OH, US.
Joel E KleinmanJohns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, US.
Nastassja KoenUniversity of Cape Town, Department of Psychiatry & Mental Health, Cape Town, Western Province, ZA.
Karestan C KoenenHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, US.
Pei-Fen KuanStony Brook University, Department of Applied Mathematics and Statistics, Stony Brook, NY, US.
Israel LiberzonTexas A&M University College of Medicine, Department of Psychiatry and Behavioral Sciences, Bryan, TX, US.
Sarah D LinnstaedtUniversity of North Carolina at Chapel Hill, Department of Anesthesiology, Chapel Hill, NC, US.
Adriana LoriEmory University, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, US.
Benjamin J LuftStony Brook University, Department of Medicine, Stony Brook, NY, US.
Jurjen J LuykxAmsterdam University Medical Center, Amsterdam Neuroscience Research Institute, Mood, Anxiety, Psychosis, Stress & Sleep Program, Amsterdam, NH, NL.
Christine E MarxDuke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, US.
Samuel A McLeanUNC Institute for Trauma Recovery, Department of Psychiatry, Chapel Hill, NC, US.
Divya MehtaQueensland University of Technology, Centre for Genomics and Personalised Health, Kelvin Grove, QLD, AU.
William MilbergVA Boston Healthcare System, GRECC/TRACTS, Boston, MA, US.
Mark W MillerBoston University School of Medicine, Psychiatry, Biomedical Genetics, Boston, MA, US.
Mary S MuffordUniversity of Cape Town, Department of Psychiatry and Mental Health, Cape Town, Western Province, ZA.
Clarisse MusanabaganwaRwanda Biomedical Center, Research Innovation and Data Science Division, Kigali, RW.
Jean MutabarukaUniversity of Rwanda, Department of Clinical Psychology, Huye, RW.
Leon MutesaUniversity of Rwanda, College of Medicine and Health Sciences, Kigali, RW.
Charles B NemeroffThe University of Texas at Austin, Department of Psychology, Austin, TX, US.
Nicole R NugentAlpert Brown Medical School, Department of Emergency Medicine, Providence, RI, US.
Holly K OrcuttNorthern Illinois University, Department of Psychology, DeKalb, IL, US.
Xue-Jun QinDuke University, Duke Molecular Physiology Institute, Durham, NC, US.
Sheila A M RauchEmory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, US.
Kerry J ResslerHarvard Medical School, Department of Psychiatry, Boston, MA, US.
Victoria B RisbroughUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Eugène RutembesaUniversity of Rwanda, Clinical Psychology, Kigali, RW, Rwanda.
Bart P F RuttenMaastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, Limburg, NL.
Soraya SeedatStellenbosch University, Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA.
Dan J SteinUniversity of Cape Town, Department of Psychiatry & Mental Health, Cape Town, Western Province, ZA.
Murray B SteinUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Sylvanus ToikumoStellenbosch University, Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA.
Robert J UrsanoUniformed Services University, Center for the Study of Traumatic Stress, Department of Psychiatry, Bethesda, Maryland, US.
Annette UwinezaUniversity of Rwanda, College of Medicine and Health Sciences, Kigali, Rwanda.
Mieke H VerfaellieBoston University School of Medicine, Department of Psychiatry, Boston, MA, US.
Eric VermettenLeiden University Medical Center, Department of Psychiatry, Leiden, ZH, NL.
Christiaan H VinkersAmsterdam UMC location Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam, Holland, NL.
Erin B WareUniversity of Michigan, Survey Research Center, Ann Arbor, MI, US.
Derek E WildmanUniversity of South Florida, College of Public Health, Tampa, FL, US.
Erika J WolfVA Boston Healthcare System, National Center for PTSD, Boston, MA, US.
Ross McD YoungQueensland University of Technology, School of Clinical Sciences, Kelvin Grove, QLD, AU.
Ying ZhaoUniversity of North Carolina at Chapel Hill, Institute for Trauma Recovery, Chapel Hill, NC, US.
Leigh L van den HeuvelStellenbosch University, Faculty of Medicine and Health Sciences, Department of Psychiatry, Cape Town, Western Cape, ZA.
PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group
Monica UddinUniversity of South Florida College of Public Health, Genomics Program, Tampa, FL, US.
Caroline M NievergeltUniversity of California San Diego, Department of Psychiatry, La Jolla, CA, US.
Alicia K SmithEmory University, Department of Gynecology and Obstetrics, Atlanta, GA, US.
Mark W LogueBoston University School of Public Health, Department of Biostatistics, Boston, MA, US.

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
The Impact of Traumatic Stress on the Methylome: implications for PTSDR01MH108826 · NIMH · EMORY UNIVERSITY · PI LOGUE, MARK W, NIEVERGELT, CAROLINE M · 2016 to 2024
$5.8M
Epigenomic Predictors of PTSD and Traumatic Stress in an African American CohortR01MD011728 · NIMHD · UNIVERSITY OF SOUTH FLORIDA · PI AIELLO, ALLISON E, UDDIN, MONICA · 2017 to 2025
$5.7M
2/3 Understanding PTSD through Postmortem Targeted Brain Multi-omicsR01MH117291 · NIMH · LIEBER INSTITUTE, INC. · PI Joel Edward Kleinman · 2018 to 2026
$5.2M
Site 3/3, Understanding PTSD through Postmortem Targeted Brain MultiomicsR01MH117292 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, KERRY J. RESSLER · 2018 to 2026
$5.0M
Emory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4M
Prediction of Alcohol Use Disorder and PTSD After Trauma in AdolescentsR01AA029090 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2022 to 2026
$4.4M
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omicsR01MH117293 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI CHARLES B NEMEROFF · 2018 to 2026
$4.3M
Biomarkers, Social and Affective Predictors of Suicidal Thoughts and Behaviors in AdolescentsR01MH105379 · NIMH · RHODE ISLAND HOSPITAL · PI NUGENT, NICOLE R · 2015 to 2019
$3.3M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
BLRD VA I01 BX002577BLRD VA I01 BX003477BLRD VA I21 BX005872BLRD VA IK6 BX006186CSRD VA I01 CX000431CSRD VA I01 CX001276CSRD VA IK2 CX000525NCATS NIH HHS UL1 TR000433NIAAA NIH HHS R01 AA029090NIA NIH HHS R03 AG051877NIA NIH HHS R21 AG061367NIA NIH HHS RF1 AG068121NICHD NIH HHS K12 HD085850NICHD NIH HHS R15 HD049907NIDA NIH HHS DP1 DA058737NIDA NIH HHS R21 DA050160NIMHD NIH HHS R01 MD011728NIMH NIH HHS R01 MH079806NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH105379NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH108826NIMH NIH HHS R01 MH117291NIMH NIH HHS R01 MH117292NIMH NIH HHS R01 MH117293NIMH NIH HHS R15 MH099521NIMH NIH HHS R21 MH085436NIMH NIH HHS R21 MH102834NIMH NIH HHS U01 MH110925NIMH NIH HHS U01 MH115485NIOSH CDC HHS U01 OH012466
6 · The paper itself

Abstract

Background: The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects include differences in DNA methylation (DNAm), an important form of epigenetic gene regulation, at multiple CpG loci across the genome. Moreover, these effects can be shared or specific to both central and peripheral tissues. Here, we aim to identify blood DNAm differences associated with PTSD and characterize the underlying biological mechanisms by examining the extent to which they mirror associations across multiple brain regions. Methods: As the Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup, we conducted the largest cross-sectional meta-analysis of epigenome-wide association studies (EWASs) of PTSD to date, involving 5077 participants (2156 PTSD cases and 2921 trauma-exposed controls) from 23 civilian and military studies. PTSD diagnosis assessments were harmonized following the standardized guidelines established by the PGC-PTSD Workgroup. DNAm was assayed from blood using either Illumina HumanMethylation450 or MethylationEPIC (850K) BeadChips. A common QC pipeline was applied. Within each cohort, DNA methylation was regressed on PTSD, sex (if applicable), age, blood cell proportions, and ancestry. An inverse variance-weighted meta-analysis was performed. We conducted replication analyses in tissue from multiple brain regions, neuronal nuclei, and a cellular model of prolonged stress. Results: We identified 11 CpG sites associated with PTSD in the overall meta-analysis (1.44e-09 < Conclusions: This study identifies 11 PTSD-associated CpGs, also leverages data from postmortem brain samples, GWAS, and genome-wide expression data to interpret the biology underlying these associations and prioritize genes whose regulation differs in those with PTSD.

Indexed as

DNA methylationgene expressionGWASpostmortem brainPTSDtrauma

Identifiers

PMID39072012
PMCPMC11275670

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.