Evidence map›Paper›PMID 39072539›Full record

ArticleJournal of research in health sciences2024

Association of rs4516035 Polymorphism with Osteoporosis in the Southeastern Iranian Population: A Case-Control Study.

Mohammad Mehdi Yaghoobi, Azadeh Samare Gholami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of research in health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mohammad Mehdi YaghoobiResearch Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.ORCID 0000-0003-1434-6224
Azadeh Samare GholamiResearch Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic polymorphisms are known to play a crucial role in the development of osteoporosis. Vitamin D

methodsThis case-control study investigated the potential association between six single-nucleotide polymorphisms (SNPs) within the

resultsNone of the patients exhibited calcium or vitamin D

conclusionDespite adequate vitamin D levels, the VDRA variant, which has lower activity, could increase the predisposition to osteoporosis in the studied population. These findings clarify the importance of genetic screening for personalized medicine and the effectiveness of prevention and treatment strategies.

Indexed as

Genetic Predisposition to DiseaseOsteoporosisPolymorphism, Single NucleotideReceptors, CalcitriolAdultAgedAllelesCalciumCase-Control StudiesCholecalciferolFemaleGene FrequencyGenotypeHumansIranMaleCalciumCholecalciferolReceptors, CalcitriolVDR protein, humanBone densityPharmacogeneticsSingle-nucleotide polymorphismVitamin D3 Receptor

Identifiers

PMID39072539
PMCPMC10999102

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.