Evidence map›Paper›PMID 39073683›Full record

ArticleMolecular biology reports2024

The role of EZH2 and its regulatory lncRNAs as a serum-based biomarker in Alzheimer's disease.

Mohsen Dibaj, Mehdi Haghi, Reza Safaralizadeh, Alia Saberi

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Mohsen DibajDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Mehdi HaghiDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. mehdihaghi@tabrizu.ac.ir.
Reza SafaralizadehDepartment of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Alia SaberiNeurology Department, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong noncoding RNAs (lncRNAs) have become a hot topic in the human nervous system. Moreover, circulating lncRNAs have been suggested as possible biomarkers for central nervous system processes and neurodegenerative diseases. The present research aimed to highlight the role of plasma lncRNAs TUG1, FEZF1-AS1, and EZH2 gene as diagnostic biomarkers in Alzheimer's disease (AD).

methodsPlasma samples for the study were provided by 100 AD patients and 100 matched controls. Real-time quantitative reverse transcriptase PCR was used to determine the plasma level of the aforementioned lncRNAs. Furthermore, the plasma level of EZH2 protein in the participants' blood was determined using the ELISA technique.

resultsIn contrast to controls, down-regulation of the EZH2 gene and protein was reported in the plasma of patients with AD. Additionally, plasma samples from AD patients showed up-and-down-regulation of the lncRNAs TUG1 and FEZF1-AS1, respectively.

conclusionOur new findings suggest that the EZH2 gene, plasma lncRNA TUG1, and FEZF1-AS1 may contribute, as valuable biomarkers, to AD diagnosis.

Indexed as

Alzheimer DiseaseBiomarkersEnhancer of Zeste Homolog 2 ProteinRNA, Long NoncodingAgedAged, 80 and overCase-Control StudiesDown-RegulationFemaleGene Expression RegulationHumansMaleMiddle AgedBiomarkersEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanRNA, Long NoncodingTUG1 long noncoding RNA, humanAlzheimer’s disease (AD)EZH2، TUG1، FEZF1-AS1Gene expressionLong non-coding RNAs (lncRNAs)

Identifiers

PMID39073683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.