Evidence map›Paper›PMID 39075111›Full record

ArticleScientific reports2024

Epigenetic aging studies of pair bonding in prairie voles.

Lindsay L Sailer, Amin Haghani, Joseph A Zoller, Caesar Z Li, Alexander G Ophir, Steve Horvath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Epigenetic age prediction.Aging cell · 2021 · on this map
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsay L Sailer *Department of Psychology, Cornell University, Ithaca, NY, 14853, USA.
Amin Haghani *Altos Labs, San Diego, USA.
Joseph A ZollerDepartment of Biostatistics, School of Public Health, University of California, Los Angeles, CA, USA.
Caesar Z LiDepartment of Biostatistics, School of Public Health, University of California, Los Angeles, CA, USA.
Alexander G OphirDepartment of Psychology, Cornell University, Ithaca, NY, 14853, USA. ophir@cornell.edu.
Steve HorvathAltos Labs, San Diego, USA. shorvath@mednet.ucla.edu.

Funding

Paul G. Allen Frontiers Group Horvath
6 · The paper itself

Abstract

The quality of romantic relationships can predict health consequences related to aging. DNA methylation-based biomarkers of aging accurately estimate chronological age. We developed several highly accurate epigenetic aging clocks, based on highly conserved mammalian CpGs, for the socially monogamous prairie vole (Microtus ochrogaster). In addition, our dual-species human-vole clock accurately measured relative age and illustrates high species conservation of epigenetic aging effects. Next, we assessed how pair bonding impacts epigenetic aging. We did not find evidence that pair-bonded voles exhibit accelerated or decelerated epigenetic aging effects in blood, ear, liver, or brain tissue. Our epigenome wide association study identified CpGs in five genes strongly associated with pair bonding: Foxp4, Phf2, Mms22l, Foxb1, and Eif1ad. Overall, we present accurate DNA methylation-based estimators of age for a species of great interest to researchers studying monogamy in animals. We did not find any evidence that sex-naive animals age differently from pair-bonded animals.

Indexed as

AgingArvicolinaeDNA MethylationEpigenesis, GeneticAnimalsCpG IslandsFemaleMalePair BondBondingDNA methylationEpigenetic clockMonogamySex-naiveVole

Identifiers

PMID39075111
PMCPMC11286801

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.