Evidence map›Paper›PMID 39075407›Full record

ReviewBMC medical informatics and decision making2024

Transformer models in biomedicine.

Sumit Madan, Manuel Lentzen, Johannes Brandt, Daniel Rueckert, Martin Hofmann-Apitius, Holger Fröhlich

Abstract readReview
In one paragraph

Review in BMC medical informatics and decision making, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  7. Review
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  9. Review
  10. Article
  11. [A Transformer-based model using laboratory indicators efficiently differentiates ovarian cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Scaling Biomedical Text-Mining: Transformers, GenAI, and Drug Discovery.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sumit MadanDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, Sankt Augustin, 53757, Germany. sumit.madan@scai.fraunhofer.de.
Manuel LentzenDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, Sankt Augustin, 53757, Germany.
Johannes BrandtSchool of Medicine, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Daniel RueckertSchool of Medicine, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Martin Hofmann-ApitiusDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, Sankt Augustin, 53757, Germany.
Holger FröhlichDepartment of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, Sankt Augustin, 53757, Germany. holger.froehlich@scai.fraunhofer.de.

Funding

Innovative Health Initiative (IHI) Joint Undertaking (JU) 101112135
6 · The paper itself

Abstract

Deep neural networks (DNN) have fundamentally revolutionized the artificial intelligence (AI) field. The transformer model is a type of DNN that was originally used for the natural language processing tasks and has since gained more and more attention for processing various kinds of sequential data, including biological sequences and structured electronic health records. Along with this development, transformer-based models such as BioBERT, MedBERT, and MassGenie have been trained and deployed by researchers to answer various scientific questions originating in the biomedical domain. In this paper, we review the development and application of transformer models for analyzing various biomedical-related datasets such as biomedical textual data, protein sequences, medical structured-longitudinal data, and biomedical images as well as graphs. Also, we look at explainable AI strategies that help to comprehend the predictions of transformer-based models. Finally, we discuss the limitations and challenges of current models, and point out emerging novel research directions.

Indexed as

Neural Networks, ComputerArtificial IntelligenceBiomedical ResearchDeep LearningHumansNatural Language ProcessingBiomedicineDeep learningLife ScienceMachine learningNeural networksTransformer

Identifiers

PMID39075407
PMCPMC11287876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.