Evidence map›Paper›PMID 39075666›Full record

ArticleJournal of investigative medicine : the official publication of the American Federation for Clinical Research2024

Glucagon-like peptide-1 receptor agonist therapy effects on glycemic control and weight in a primary care clinic population.

Eric J Palecek, Margaret M Kimzey, Jingwen Zhang, Justin Marsden, Chloe Bays, William P Moran, Patrick D Mauldin, Andrew D Schreiner

Abstract read
In one paragraph

Article in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eric J PalecekDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Margaret M KimzeyDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Jingwen ZhangDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Justin MarsdenDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Chloe BaysDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
William P MoranDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Patrick D MauldinDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Andrew D SchreinerDivision of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Funding

Improving the Diagnosis of Liver Disease in Primary Care Patients with Abnormal Liver FunctionK23DK118200 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCHREINER, ANDREW DAVID · 2018 to 2022
$866k
Improving the Diagnosis and Fibrosis Risk Assessment of Nonalcoholic Fatty Liver Disease in Primary Care Patients with Abnormal Liver ChemistriesR03DK129558 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCHREINER, ANDREW DAVID · 2022 to 2023
$226k
NIDDK NIH HHS K23 DK118200NIDDK NIH HHS R03 DK129558
6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonist (GLP-1a) medications have been shown in randomized controlled trials (RCTs) to have consistent and impressive effectiveness in lowering hemoglobin A1c (HbA1c) and weight, but limited data exist on the efficacy of GLP-1a medications in clinical practice. We studied the association between GLP-1a therapy and changes in weight and HbA1c in a real-world patient population. In this retrospective cohort study of patients seen in a primary care clinic between 2012 and 2021, we examined the change in weight and HbA1c over 12 months in a cohort of patients with at least one prescription for a GLP-1a. Within this cohort, treatment was defined as having ≥2 GLP-1a prescriptions at a therapeutic dosage separated by ≥10 months. The cohort included 693 patients of whom 393 (57%) were treated with GLP-1a therapy. The treatment group had a mean change in body mass index (BMI) of -0.83 kg/m

Indexed as

Body WeightGlucagon-Like Peptide-1 Receptor AgonistsGlycemic ControlPrimary Health CareAgedBlood GlucoseDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansMaleMiddle AgedRetrospective StudiesBlood GlucoseGlucagon-Like Peptide-1 Receptor AgonistsGlycated Hemoglobinadultglucagon-like peptide-1 receptorglycated hemoglobinobesityretrospective studiesType 2 diabetes mellitusweight loss

Identifiers

PMID39075666
PMCPMC11581925

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.