Evidence map›Paper›PMID 39076096›Full record

ArticleCombinatorial chemistry & high throughput screening2025

Effect and Mechanism of 6-Gingerol against Precancerous Lesions of Gastric Cancer Based on Network Pharmacology and

Jingyu Xu, Cian Zhang, Ling Wang, Meiling Wang, JIayu Liang, Yanlong Yang, Xuan Zhang

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Article in Combinatorial chemistry & high throughput screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingyu XuDepartment of Traditional Chinese Medicine, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Cian ZhangDepartment of Traditional Chinese Medicine, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
Ling WangDepartment of Traditional Chinese Medicine, No.905 Hospital of Navy, Shanghai, 200052, China.
Meiling WangDepartment of Traditional Chinese Medicine, No.905 Hospital of Navy, Shanghai, 200052, China.
JIayu LiangDepartment of Traditional Chinese Medicine, No.905 Hospital of Navy, Shanghai, 200052, China.
Yanlong YangSchool of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China.
Xuan ZhangDepartment of Traditional Chinese Medicine, No.905 Hospital of Navy, Shanghai, 200052, China.

Funding

State Key Program of the National Natural Science Foundation of China 81202678, 81302933Youth Startup Foundation of The Second Military Medical University 2012QN17
6 · The paper itself

Abstract

backgroundPrecancerous Lesions of Gastric Cancer (PLGC) are critical in the secondary prevention of gastric cancer. Despite the notable effects of natural products on PLGC, the specific mechanisms by which compounds, like 6-gingerol, influence these lesions are not fully understood.

aimsThis study aimed to confirm the effect and mechanism of 6-gingerol in the treatment of precancerous lesions of gastric cancer (PLGC).

objectiveThe objective of this study was to elucidate the effects and mechanisms of 6-gingerol against PLGC using network pharmacology and in vitro experiments.

methodsWe employed network pharmacology to identify potential targets and pathways influenced by 6-gingerol, followed by validation through

resultsNetwork pharmacology analysis highlighted the PI3K/Akt signaling pathway as significantly influenced by 6-gingerol.

conclusionThis study demonstrated that 6-gingerol acts as an effective agent against PLGC, with clear dose-dependent effects that pave the way for further experimental and clinical exploration.

Indexed as

CatecholsFatty AlcoholsNetwork PharmacologyPrecancerous ConditionsStomach NeoplasmsApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionCatecholsFatty AlcoholsgingerolPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt6-gingerolexperimental verificationgastric cancer.network pharmacologypharmacological mechanismsPrecancerous lesions of gastric carcinoma

Identifiers

PMID39076096

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.