Evidence map›Paper›PMID 39076483›Full record

ArticleReviews in cardiovascular medicine2024

Coronary Artery Plaque Phenotype and 5-Year Clinical Outcomes in Older Patients with Non-ST Elevation Acute Coronary Syndrome.

Francesca Rubino, Salvatore Brugaletta, Gregory Mills, Graziella Pompei, Roberto Scarsini, Flavio Ribichini, Lorenz Räber, Vijay Kunadian

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reviews in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01933581 (ICON1), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01933581 completednot on this map

ICON1: A Study to Improve Cardiovascular Outcomes in High Risk PatieNts With Acute Coronary Syndrome

TypeobservationalSponsorNewcastle-upon-Tyne Hospitals NHS TrustRan2012 to 2016Enrolled300ConditionsAcute Coronary Syndrome
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca RubinoTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-2309-1032
Salvatore BrugalettaHospital Clínic, Cardiovascular Clinic Institute, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.ORCID https://orcid.org/0000-0001-5845-1435
Gregory MillsTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-7981-3594
Graziella PompeiTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-1901-0703
Roberto ScarsiniDivision of Cardiology, Department of Medicine, University of Verona, 37126 Verona, Italy.ORCID https://orcid.org/0000-0002-5916-8882
Flavio RibichiniDivision of Cardiology, Department of Medicine, University of Verona, 37126 Verona, Italy.ORCID https://orcid.org/0000-0002-6662-0304
Lorenz RäberDepartment of Cardiology, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0003-0824-3026
Vijay KunadianTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0003-2975-6971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lesions with thin-cap fibroatheroma (TCFA), small luminal area and large plaque burden (PB) have been considered at high risk of cardiovascular events. Older patients were not represented in studies which demonstrated correlation between clinical outcome and plaque characteristics. This study aims to investigate the prognostic role of high-risk plaque characteristics and long-term outcome in older patients presenting with non-ST elevation acute coronary syndrome (NSTEACS). Methods: This study recruited older patients aged Results: Eighty-six patients with 225 vessels undergoing VH-IVUS at baseline completed 5-year clinical follow-up. Patients with minimal lumen area (MLA) Conclusions: Small luminal area appears as the major prognostic factor in older patients with NSTEACS at long-term follow-up. Combination of TCFA, MLA Clinical Trial Registration: NCT01933581.

Indexed as

major adverse cardiovascular eventsminimal lumen areanon-ST elevation acute coronary syndromeolder patientsplaque burdenthin-cap fibroatheromavirtual-histology intravascular ultrasound

Identifiers

PMID39076483
PMCPMC11267207

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.