ArticleFrontiers in neuroanatomy2024
Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models.
Article in Frontiers in neuroanatomy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- 3D Light sheet microscopy reveals aging osteoarthritis-associated joint-innervated nerve remodeling in mouse knee joints.Osteoarthritis and cartilage · 2026Article
- Structural osteoarthritis pathogenesis correlates with distinct pain and dysfunction profiles after ACL injury in rats.Lab animal · 2026Article
- A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease.Annals of the rheumatic diseases · 2026Article
- Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium.Osteoarthritis and cartilage · 2026Article
- Mechanistic insights into cartilage-sensory nerve crosstalk in osteoarthritis progression.Journal of orthopaedic translation · 2026Review
- Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses.Laboratory investigation; a journal of technical methods and pathology · 2026Review
- FM-dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain.British journal of pharmacology · 2026Article
- Towards an individualised approach to pain management in inflammatory arthritis.Therapeutic advances in musculoskeletal disease · 2026Review
- Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease-Specific Neurovascular Plasticity Underlying the Structure-Pain Relationship.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.bioRxiv : the preprint server for biology · 2025Article
- Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles.Nanoscale · 2025Article
- O-GlcNAc transferase influences the progression of degenerative cartilage disease in lumbar facet joint osteoarthritis through FoxO1 and EGR1.Cell death discovery · 2025Article
- Intraarticular resiniferatoxin, a potent TRPV1 agonist, for treatment of osteoarthritic pain.Pain management · 2025Review
- A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons.bioRxiv : the preprint server for biology · 2025Article
- Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review.Osteoarthritis and cartilage open · 2025Review
- Pain mechanisms in osteoarthritis: recent discoveries and opportunities ahead.Connective tissue research · 2025Review
- Insights into Vascular Changes in Hip Degenerative Disorders: An Observational Study.Journal of clinical medicine · 2025Article
- Synovial fluid as a complex molecular pool contributing to knee osteoarthritis.Nature reviews. Rheumatology · 2025Review
- Decoding the impact of exercise and αCGRP signaling on murine post-traumatic osteoarthritis progression.Arthritis research & therapy · 2025Article
- Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement.Journal of visualized experiments : JoVE · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Objective: Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and late-stage OA, using four distinct experimental mouse models. Methods: Sham surgery, destabilization of the medial meniscus (DMM), partial meniscectomy (PMX), or non-invasive anterior cruciate ligament rupture (ACLR) was performed in the right knee of 10-12-week old male C57BL/6 Na Results: Progressive OA developed in the medial compartment after DMM, PMX, and ACLR. Synovitis and associated neo-innervation of the synovium by nociceptors peaked in early-stage OA. In the subchondral bone, channels containing sprouting nociceptors appeared early, and progressed with worsening joint damage. Two-year old mice developed primary OA in the medial and the lateral compartment, accompanied by nociceptor sprouting in the synovium and the subchondral bone. All four models showed increased nerve signal in osteophytes. Conclusion: These findings suggest that anatomical neuroplasticity of nociceptors is intrinsic to OA pathology. The detailed description of innervation of the OA joint and its relationship to joint damage might help in understanding OA pain.
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