ArticleProceedings of the National Academy of Sciences of the United States of America2024
Identification and characterization of a small-molecule metallophore involved in lanthanide metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multi-omics insights into bacterial and fungal bioremediation of Potentially Toxic Elements (PTEs): a critical overview of their applications.World journal of microbiology & biotechnology · 2026Review
- Source-Independent Enrichment of Light Lanthanides: Microbial Mobilization, Selective Uptake, and Intracellular Storage.Environmental microbiology · 2026Article
- Synthesis of two methylolanthanin derivatives and the investigation of their lanthanide and iron binding capabilities.Dalton transactions (Cambridge, England : 2003) · 2026Article
- A frameshift mutation drives divergent biosynthesis of metallophores inbioRxiv : the preprint server for biology · 2026Article
- Article
- A systems-level view of metabolic impact of copper and methane valorization potential inMetabolic engineering communications · 2026Article
- Beneath the surface: expanding the known repertoire of methylotrophic metabolism.Applied and environmental microbiology · 2026Article
- Functional organization and regulatory logic of theApplied and environmental microbiology · 2026Review
- Article
- Computational mass spectrometry and genome mining guided discovery of metallophores produced by Microbulbifer.ISME communications · 2026Article
- Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron.Chembiochem : a European journal of chemical biology · 2026Article
- Expanding on the ability of trivalent actinides to support microbial alcohol metabolism in evolved methylotrophic bacterium.Communications chemistry · 2025Article
- XoxF and the Calvin-Benson cycle mediate lanthanide-dependent growth on methanol inApplied and environmental microbiology · 2025Article
- Inverse stable isotope labeling (InverSIL) links predicted catecholate siderophore gene clusters to their products in diverse bacteria.bioRxiv : the preprint server for biology · 2025Article
- Diel cycle of lanthanide-dependent methylotrophy by TMED127/Methylaequorales bacteria in oligotrophic surface seawater.Applied and environmental microbiology · 2025Article
- Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition.Current opinion in chemical biology · 2025Review
- Extensive and diverse lanthanide-dependent metabolism in the ocean.The ISME journal · 2025Article
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
- Whole genome sequencing, characterization and analysis of coronene degrading bacterial strain Halomonas elongata.PloS one · 2025Article
- A novel in-silico model explores LanM homologs among Hyphomicrobium spp.Communications biology · 2024Article
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9 authors.
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Abstract
Many bacteria secrete metallophores, low-molecular-weight organic compounds that bind ions with high selectivity and affinity, in order to access essential metals from the environment. Previous work has elucidated the structures and biosynthetic machinery of metallophores specific for iron, zinc, nickel, molybdenum, and copper. No physiologically relevant lanthanide-binding metallophore has been discovered despite the knowledge that lanthanide metals (Ln) have been revealed to be essential cofactors for certain alcohol dehydrogenases across a diverse range of phyla. Here, we report the biosynthetic machinery, the structure, and the physiological relevance of a lanthanophore, methylolanthanin. The structure of methylolanthanin exhibits a unique 4-hydroxybenzoate moiety which has not previously been described in other metallophores. We find that production of methylolanthanin is required for normal levels of Ln accumulation in the methylotrophic bacterium
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