Evidence map›Paper›PMID 39079333›Full record

ArticleEnvironment international2024

First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.

Ixel Hernandez-Castro, Sheryl L Rifas-Shiman, Pi-I D Lin, Jorge E Chavarro, Diane R Gold, Mingyu Zhang, Noel T Mueller, Tamarra James-Todd, Brent Coull, Marie-France Hivert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ixel Hernandez-CastroDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Pi-I D LinDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Jorge E ChavarroDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Diane R GoldChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Mingyu ZhangDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Noel T MuellerDepartment of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Tamarra James-ToddDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Brent CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA; Diabetes Unit, Massachusetts General Hospital, Boston, MA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, USA. Electronic address: andresca@stanford.edu.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$44.6M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Paul S. Maclean · 1995 to 2026
$32.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
NICHD NIH HHS R01 HD034568NIDDK NIH HHS P30 DK048520NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES031259NIEHS NIH HHS R24 ES030894NIH HHS UG3 OD023286NIH HHS UH3 OD023286
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) such as preeclampsia and gestational hypertension are major contributors to maternal and child morbidity and mortality. Previous studies have reported associations with selected metals and vitamins but are limited in sample size and non-prospective study designs. We evaluated prospective associations of metal mixtures with HDP and tested interactions by vitamins. STUDY

designWe measured first trimester (median = 10.1 weeks) concentrations of essential (copper, magnesium, manganese, selenium, zinc) and nonessential (arsenic, barium, cadmium, cesium, mercury, lead) metals in red blood cells (n = 1,386) and vitamins (B

resultsThe majority of participants were non-Hispanic white (72.5 %), never smokers (68.5 %) with a mean (SD) age of 32.3 (4.6) years. Fifty-two (3.8 %) developed preeclampsia and 94 (6.8 %) gestational hypertension. A doubling in first trimester erythrocyte copper was associated with 78 % lower odds of preeclampsia (OR=0.22, 95 % confidence interval: 0.08, 0.60). We also observed significant associations between higher erythrocyte total arsenic and lower odds of preeclampsia (OR=0.80, 95 % CI: 0.66, 0.97) and higher vitamin B

conclusionLower levels of a first-trimester essential metal mixture were associated with an increased risk of preeclampsia, primarily driven by copper. No associations were observed between other metals and HDP after adjustment for confounders and diet.

Indexed as

Environmental PollutantsMaternal ExposureMetalsVitaminsAdultDietFemaleHumansHypertensionPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstEnvironmental PollutantsMetalsVitaminsGestational hypertensionHypertensive disorders of pregnancyMetalsPreeclampsiaPrenatal environmental exposures

Identifiers

PMID39079333
PMCPMC11389723

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.