Evidence map›Paper›PMID 39080417›Full record

ArticleScientific reports2024

In vivo vitamin D targets reveal the upregulation of focal adhesion-related genes in primary immune cells of healthy individuals.

Ranjini Ghosh Dastidar, Julia Jaroslawska, Marjo Malinen, Tomi-Pekka Tuomainen, Jyrki K Virtanen, Igor Bendik, Carsten Carlberg

Registry-linked trialAbstract readClinical Study
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537027 (Comparing the Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 Treatment on Changes of the Transcriptome of Low Vitamin D Responders), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537027 phase1completednot on this map

Comparing the Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 Treatment on Changes of the Transcriptome of Low Vitamin D Responders

TypeinterventionalSponsorUniversity of Eastern FinlandRan2018 to 2018Enrolled40ConditionsVitamin D Receptor Target Gene Expression, Serum 25(OH)D ConcentrationArmsVitamin D3
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. EarlyFrontiers in immunology · 2025
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ranjini Ghosh DastidarInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, Ul. J. Tuwima 10, 10-748, Olsztyn, Poland.
Julia JaroslawskaInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, Ul. J. Tuwima 10, 10-748, Olsztyn, Poland.
Marjo MalinenDepartment of Forestry and Environmental Engineering, South-Eastern Finland University of Applied Sciences, Kouvola, Finland.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Igor Bendikdsm-Firmenich AG, Health, Nutrition and Care (HNC), Kaiseraugst, Switzerland.
Carsten CarlbergInstitute of Animal Reproduction and Food Research, Polish Academy of Sciences, Ul. J. Tuwima 10, 10-748, Olsztyn, Poland. c.carlberg@pan.olsztyn.pl.

Funding

Horizon 2020 952601National Science Center 2023/49/B/NZ9/00402
6 · The paper itself

Abstract

Vitamin D modulates innate and adaptive immunity, the molecular mechanisms of which we aim to understand under human in vivo conditions. Therefore, we designed the study VitDHiD (NCT03537027) as a human investigation, in which 25 healthy individuals were supplemented with a single vitamin D

Indexed as

Focal AdhesionsLeukocytes, MononuclearVitamin DAdultCholecalciferolDietary SupplementsFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMiddle AgedTranscriptomeUp-RegulationYoung AdultCholecalciferolVitamin DFocal adhesionTranscriptomeVitamin DVitamin D intervention studyVitamin D response indexVitamin D target genes

Identifiers

PMID39080417
PMCPMC11289414

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.